Assessment of Tumor Response in Mice with Ovarian Peritoneal Carcinomatosis using Doppler Ultrasound of the Superior Mesenteric Artery and Celiac Trunk |
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| Authors: | Matthias Barral Cynthia Pimpie Rachid Kaci Iman Al-Dybiat Massoud Mirshahi Marc Pocard Philippe Bonnin |
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| Institution: | 2. Anatomopathologie, hôpital Lariboisière, Université de Paris, Paris, France;3. Chirurgie Digestive et cancérologique, hôpital Lariboisière, Université de Paris, Paris, France;4. Physiologie Clinique–Explorations-Fonctionnelles, hopital Lariboisière, Université de Paris, Paris, France;5. INSERM U1148, LVTS, hôpital Bichat, Université de Paris, Paris, France |
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| Abstract: | The goal of the work described here was to assess the performance of Doppler ultrasound (US) of the superior mesenteric artery (SMA) and celiac trunk (CT) in the evaluation of tumor response in female mice with ovarian peritoneal carcinomatosis treated either with bevacizumab or with carboplatin. Compared with untreated mice, carboplatin-treated mice had a lower weight (23.3 ± 2.0 vs. 27.9 ± 2.9 g, p < 0.001), peritoneal carcinomatosis index (PCI, 11 ± 3 vs. 28 ± 6, p < 0.001), Ki67-positive staining surfaces (p < 0.001), vascular density (p < 0.001), mean blood flow velocity (mBFVel) in the SMA (7.0 ± 1.4 vs. 10.9 ± 1.8 cm/s, p < 0.001) and CT (8.0 ± 1.8 vs. 14.3 ± 4.6 cm/s, p < 0.001) and no ascites. Weight and mBFVel were similar in bevacizumab-treated and untreated mice. The mBFVels in the SMA and CT correlated with the PCI used as an estimation of the tumor burden, R = 0.70 (p < 0.0001) and R = 0.65 (p < 0.0001), respectively. Doppler US allows non-invasive assessment of the effects of anticancer therapy in ovarian peritoneal carcinomatosis-induced mice. |
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