2型糖尿病患者中高尿酸血症的研究

目的 研究2型糖尿病患者中的高尿酸血症与血压、脂代谢紊乱及胰岛素抵抗、代谢综合征的关系。方法 收集1472例2型糖尿病患者的血尿酸及其他临床资料并进行分析。结果 高尿酸血症的患病率19％；血尿酸高于均数组男性更多、更胖，收缩压和舒张压增高，甘油三酯（TG）增高，高密度脂蛋白胆田醇（HDL-C）降低，胰岛素抵抗指数增高；血尿酸与空腹胰岛素、胰岛素抵抗指数（HOMA-IR）呈正相关；男性、腰围、舒张压和TG是预测血尿酸升高的主要因素。结论 2型糖尿病患者的血尿酸水平的升高与肥胖、脂代谢紊乱、血压升高、胰岛素抵抗、代谢综合征密切相关。

Study on hyperuricemia of patients with type two diabetes

Objective To evaluate the relationship between blood pressure,hyperlipemia,insulin resistance,metabolic syndrome and hyperuricemia of type two diabetes.Method Serum uric acid and other clinical data of(1 472) type two diabetes were collected.Results The prevalence of hyperuricemia was 19% in type two diabetes.The patients with higher serum uric acid were more fat,more male,higher blood pressure,higher triglycerides(TG),lower high-density lipoproteins(HDL) cholesterol and higher homeostasis model assessment(HOMA) insulin resistance index than the contrast patients.Serum uric acid was positive correlated with serum insulin and HOMA insulin resistance index.Sex(male),waist circumstance diatolic pressure and TG were the predictors of hyperuricemia.Conclusion Hyperuricemia of type two diabetes was closely correlated with obesity,hyperlipemia,hypertension,insulin resistance and metabolic syndrome.