不稳定性心绞痛患者血清Vaspin水平及与血管内皮细胞黏附分子的相关性

目的 观察不稳定性心绞痛（UA）患者血清内脏脂肪组织来源的丝氨酸蛋白酶抑制剂（visceral adipose tissue derived serine protease inhibitor, Vaspin）水平，并探讨血清Vaspin与可溶性血管细胞黏附分子1（sVCAM 1）、可溶性细胞间黏附分子1（sICAM 1）之间的相关性。方法 采用定量夹心酶联免疫检测技术对90例不稳定性心绞痛患者（UA组）、90例稳定性心绞痛（SA）患者（SA组）及80例健康对照者（对照组）血清Vaspin、sVCAM 1、sICAM 1水平的变化进行检测，同时常规检测其他临床生物化学指标。在UA组，采用Pearson相关检验对血清Vaspin与sVCAM 1、sICAM 1、高敏C反应蛋白（hs CRP）及其他生物化学指标进行相关性分析。结果 UA组血清sVCAM 1、sICAM 1水平显著高于SA组（分别P＜0.01）及对照组（均P＜0.01）。UA组血清Vaspin水平与sVCAM 1（r＝0.354，P=0.001）、sICAM 1（r＝0.287，P=0.006）、hs CRP（r＝0.3111，P=0.003）水平呈显著负相关。结论 不稳定性心绞痛患者血清Vaspin水平显著降低，并与sVCAM 1、sICAM 1、hs CRP呈负相关，提示血清Vaspin与血管内皮损伤、冠心病严重程度密切相关，可能为不稳定性心绞痛患者重要的生物标志物。

Change of serum vaspin level in patients with unstable angina and correlation with vascular endothelial cell adhesion molecules

Objective To observe the serum levels of visceral adipose tissue derived serine protease inhibitor (Vaspin) in patients with unstable angina (UA) and to explore the correlation between serum Vaspin and soluble vascular cell adhesion molecule 1 (sVCAM 1), soluble intercellular cell adhesion molecule 1 (sICAM 1). Methods Quantitative sandwich enzyme linked immunoassay technology was used to detect the changes of serum Vaspin, sVCAM 1 and sICAM 1 levels in 90 patients with UA(UA group), 90 patients with stable angina (SA group) and 80 healthy subjects (control group). Other clinical biochemical indicators were routinely detected at the same time. In UA group, the relationships between serum Vaspin and sVCAM 1, sICAM 1, high sensitivity C reactive protein (hs CRP) and other biochemical indicators were analyzed by Pearson correlation analysis. Results The levels of serum sVCAM 1 and sICAM 1 in UA group were significantly higher than those in SA group（respectively P＜0.01） and control group（respectively P＜0.01）. Serum Vaspin levels in UA group were significantly negatively correlated with sVCAM 1 (r＝0.354，P=0.001), sICAM 1 (r＝0.287，P=0.006), and hs CRP (r＝0.3111，P=0.003) levels. Conclusion The levels of serum Vaspin in patients with UA are significantly decreased, and are negatively correlated with sVCAM 1, sICAM 1 and hs CRP, suggesting that serum Vaspin is closely related to vascular endothelial damage and the severity of coronary artery disease, and may be important biomarkers of UA in patients.