阻塞性睡眠呼吸暂停综合征患者血管内皮功能损害和相关炎症因子的研究

目的探讨阻塞性睡眠呼吸暂停综合征（OSAHS）严重程度和血管内皮功能损害及相关炎症因子的关系。方法选择在本院呼吸科和心内科住院的0sAHS患者120例，并按0sAHs的严重程度分为轻度、中度和重度3组，分别测定3组患者的血管性血友病因子（vWF）、C反应蛋白（CRP）、白细胞介素6（IL-6）及一氧化氮（N0）的水平，并应用高频超声检测血管内皮功能的主要指标（肱动脉基础内径，反应性充血后肱动脉内径变化率，口服硝酸甘油后肱动脉内径变化率，峰值流速变化率）。结果重度OSAHS组的vWF、CRP、IL－6水平分别为（356．3±59．7）％、（35．54-15．2）mg／L、（41．2±8．5）ng／L明显高于中度的（248．7±51．3）％、（26．2±12．3）mg／L、（34．7±7．6）ng／L和轻度组的（135．8±48．6）％、（15．3±8．9）mg／L、（25．9±6．8）ng／L，中度组明显高于轻度组（P〈0．05），而重度组反应性充血后肱动脉内径变化率、峰值流速变化率、NO平均水平分别（7．19±2．08）％、（46．86±9．98）％、（7．8±5．6）μmol／L明显低于中度组的（13．45±3．01）％、（54．26±10．05）％、（10．6±6．1）／μmol／L和轻度组的（21．10±2．25）％、（67．215±11．86）％、（15．6±7．3）μmol／L，中度组低于轻度组（P〈0．05）。结论0SAHS严重程度和血管内皮功能损害程度及其炎症因子密切相关。

Clinical study of vascular endothelial dysfunction and inflammation factors in patients with obstructive sleep apnea-hypopnea syndrome

Objective To analyze the relationship between the vascular endothelial dysfunction,the inflammation factors and the severity of OSAHS.Methods 120 patients who had been diagnosed of OSAHS were selected,by severity they were grouped into slight group,medium group and serious group,then serum von Willebrand factor(vWF),C-reactive protein(CRP),interleukin-6(IL-6),nitric oxide(NO) were detected,and main data(baseline of brachial artery,the flow-mediated dilatation and the nitroglycerin-induced dilatation,the pea...