LDL-C/HDL-C在2型糖尿病合并冠心病中的预测价值

目的 探讨2型糖尿病合并冠心病患者血脂与冠状动脉粥样硬化程度的相关性。方法 选取2型糖尿病患者286例,根据冠状动脉造影情况分为2型糖尿病合并冠状动脉狭窄<50％（A组）；2型糖尿病并冠状动脉狭窄≥50％（B组）。比较各组间一般资料及生化等指标。结果 两组糖尿病病程、糖化血红蛋白、低密度脂蛋白胆固醇（LDL C）、高密度脂蛋白胆固醇（HDL C）、LDL C/HDL C比较差异有统计学意义；多元Logistic回归分析显示：LDL C/HDL C是2型糖尿病患者发生冠状动脉粥样硬化的独立危险因素；ROC曲线结果显示：LDL C/HDL C最佳临界点为2.53时敏感度为77.6%，特异度为82.3%。结论 LDL C/HDL C在预测2型糖尿病患者发生冠状动脉病变优于单纯LDL C和HDL C。

The predictive value of LDL C/HDL C in type 2 diabetes mellitus with coronary heart disease

Objective To investigate the correlation between blood lipids and the degree of coronary atherosclerosis in patients with type 2 diabetes and coronary heart disease. Methods According to the status of coronary angiography, a total of 286 patients with type 2 diabetes were divided into two groups: type 2 diabetes with coronary artery stenosis <50%(Group A), and type 2 diabetes with coronary artery stenosis≥50% (Group B). General information and biochemical indicators between two groups were compared. Results There was significant difference between two groups in the course of diabetes, hemoglobin A1c (HbA1c), low density lipoprotein cholesterol(LDL C), high density lipoprotein cholesterol (HDL C), and LDL C/HDL C（P＜0.05). Logistic multivariate regression analysis showed that: LDL C/HDL C was an independent risk factor for coronary atherosclerosis in patients with type 2 diabetes. The ROC curve results showed that the optimal critical point of LDL C/HDL C was 2.53, at this time the sensitivity was 77.6% and the specificity was 82.3%.Conclusion LDL C/HDL C is better than LDL C and HDL C in predicting coronary artery disease in patients with type 2 diabetes.