奥氮平治疗精神分裂症对患者症状、安全性评分及相关血清因子的影响

目的 分析奥氮平对精神分裂症患者不良反应量表(TESS)评分、阴性和阳性综合征量表(PANSS)评分、简明精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分、病情严重程度(SI)评分等相关评分及神经生化标志物(S100β)、中间丝相关蛋白(Repetin)、空腹血糖(FPG)、餐后2h血糖(2hPG)等相关因子的的影响。方法 选取我院于2018年3月至2020年1月收治的精神分裂症患者82例,根据入院后用药方案不同分为两组。对照组采用阿立哌唑治疗,观察组采用奥氮平治疗,检测两组治疗前后S100β、Repetin、FPG、2hPG水平,比较两组治疗前后PANSS评分、MMSE评分、MoCA评分、SI评分及TESS评分。结果 治疗前,两组S100β、Repetin、FPG、2hPG水平差异无统计学意义(P>0.05)。治疗后,观察组Repetin水平高于对照组(P<0.05),S100β、FPG、2hPG水平低于对照组(P<0.05)。治疗前,两组各项PANSS评分、MMSE、MoCA评分、SI评分差异无统计学意义(P>0.05)。治疗后,观察组各项PANSS评分、SI评分低于对照组(P<0.05),MMSE评分、MoCA评分高于对照组(P<0.05)。治疗前,两组TESS评分差异无统计学意义(P>0.05)。治疗后6周、8周时,观察组TESS评分低于对照组(P<0.05)。结论 奥氮平治疗精神分裂症,PANSS评分下降显著,改善患者认知功能,安全性高。

Effect of olanzapine on symptoms,safety scores and related serum factors of schizophrenia in patients

Objective To analyze the effect of olanzapine on relevant scoring of schizophrenia in patients, including the adverse reaction scale (TESS), the Positive and Negative Syndrome Scale (PANSS), the Mini Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), severity of illness (SI); as well as the effect of olanzapine on related factors such as neurobiochemical markers, S100beta protein (S100β), intermediate filament and associated protein, repetin (Rptn), fasting plasma glucose (FPG), 2-h postprandial blood glucose (2hPG), ect. Methods Totally 82 schizophrenic inpatients from March 2018 to January 2020 were selected and divided into two groups as different medication schemes after admission. The observation group was treated with drug intervention of olanzapine and the control group with drug intervention of aripiprazole. Before and after treatment, the levels of S100β, Rptn, FPG and 2hPG was measured, PANSS score, MMSE score, MOCA score, SI score and TESS score were compared between groups. Results There was no significant difference in S100β, Rptn, FPG, 2hPG between groups before treatment (P>0.05). Rptn was higher (P<0.05) and S100β, FPG, 2hPG was lower (P<0.05) in observation group when compared with control group, respectively. Difference of PANSS, MMSE, MoCA, SI scores was no significant between groups before treatment (P>0.05). PANSS, SI scorces in observation group were lower than those in control group (P<0.05) and MMSE, MoCA scores higher than those in control group (P<0.05). There was no significant difference in TESS scores between groups before treatment (P>0.05). TESS scores on weeks 6, week 8 post-treatment in observation group were lower than those in control group (P<0.05). Conclusion PANSS score decreases significantly by the application of olanzapine for schizophrenia, which is capable improving patient's cognitive function, and with high safety.