心肌型脂肪酸结合蛋白与新型冠状病毒肺炎轻重症的相关性

目的 分析轻型/重型新型冠状病毒肺炎(COVID-19)患者的临床特征,探讨心肌型脂肪酸结合蛋白(H-FABP)与COVID-19轻重症的相关性。方法 回顾性分析2022年6月前重庆大学附属三峡医院收治的超敏肌钙蛋白T(hs-cTnT)表达阴性的COVID-19患者40例,根据《新型冠状病毒肺炎诊疗方案(试行第八版)》诊断标准,将患者分为轻型和重型两组,比较两组外周血中H-FABP表达水平差异。结果 符合纳入标准的COVID-19患者共40例,其中轻型组20例,重型组20例,与轻型组相比,重型组年龄更大(41.9±10.5) vs (58.2±16.3)岁],且合并糖尿病比例更高(P均<0.05)。通过比较两组血清H-FABP表达水平发现,重型组H-FABP水平明显高于轻型组(3.97±1.80) vs (6.88±3.90) μg/L,P<0.05]。结论 在hs-cTnT表达阴性的COVID-19患者中,血清H-FABP表达水平与COVID-19疾病严重程度相关,H-FABP可能作为一个更加敏感且独立的心肌损伤因子用于COVID-19疾病分型。

Correlation between heart type fatty acid binding protein and mild & severe COVID-19

Objective To analyze the clinical characteristics of patients with mild & severe corona virus disease 2019 (COVID-19) and explore the correlation between herart fatty acid binding protein(H-FABP)and mild & severe COVID-19. Methods Totally 40 patients with negative expression of high-sensitivity troponin T (hs-cTnT) admitted to the Chongqing University Three Gorges Hospital before June 2022 were retrospectively analyzed. According to the diagnostic criteria of “Diagnosis and Treatment Protocol for COVID-19 (Trial Version 8)”, the patients were enrolled into the mild and severe groups. The expression levels of H-FABP in peripheral blood were compared between the two groups. Results Eligible 40 COVID-19 patients representing 20 cases in the mild group and 20 cases in the severe group were included. Compared with the mild group, the patients in the severe group were older (41.9±10.5] vs 58.2±16.3]) years, and the proportion of patients with diabetes was higher (all P<0.05). H-FABP level in the severe group was significantly higher than that in the mild group (3.97±1.80] vs 6.88±3.90] μg/L; P<0.05], respectively). Conclusion In COVID-19 patients with negative hs-cTnT expression, serum H-FABP expression level is associated with the severity of COVID-19 disease. H-FABP may serve as a more sensitive and independent myocardial injury factor to contribute to the disease typing of COVID-19.