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Importance of measuring products of non-enzymatic glycation of proteins |
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| Authors: | Lapolla Annunziata Traldi Pietro Fedele Domenico |
| Institution: | Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Università di Padova, Padova, Italy. annunziata.lapolla@unipd.it |
| Abstract: | Non-enzymatic glycation products are a complex and heterogeneous group of compounds which accumulate in plasma and tissues in diabetes and renal failure. There is emerging evidence that these compounds may play a role in the pathogenesis of chronic complications associated with diabetes and renal failure. So measurement of the products of non-enzymatic glycation has a twofold meaning: on one hand, measurement of early glycation products can estimate the extent of exposure to glucose and the subject's previous metabolic control; on the other hand, measurement of intermediate and late products of the glycation reaction is a precious instrument in verifying the relationship between glycation products and tissue modifications. This review summarizes current knowledge about the diagnostic utility of measuring non-enzymatic glycation products. |
| Keywords: | ADA American Diabetes Association AGE Advanced Glycation End-Products CAPD continuous ambulatory peritoneal dialysis DCCT Diabetes Control and Complications Trial CML carboxymethyl lysine EDIC Epidemiology of Diabetes Interventions and Complications EGF Endothelial Growth Factor ELISA Enzyme Linked Immunosorbent Assay GC/MS Gas Chromatography/Mass Spectrometry HD hemodialysis HPLC High Performance Liquid Chromatography IFCC International Federation of Clinical Chemistry IGF1 Insulin-like Growth Factor 1 IgG Immunoglobulin type G LC/ESI/MS Liquid Chromatography/Electrospray Ionization Mass Spectrometry LDL Low Density Lipoprotein MALDI/MS Matrix-Assisted Laser Desorption Mass Spectrometry NBT Nitro Blue Tetrazolium NF-κB Nuclear Factor κB PDGF Platelet Derived Growth Factor RAGE receptor for AGE RCO reactive dicarbonyl compounds RIA Radio Immunoassay TNF-α Tumor Necrosis Factor α VCAM Vascular Cell Adhesion Molecule |
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