Sacituzumab govitecan,a novel,third-generation,antibody-drug conjugate (ADC) for cancer therapy |
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| Authors: | David M Goldenberg Robert M Sharkey |
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| Institution: | 1. Center for Molecular Medicine and Immunology , Mendham, New Jersey, USA dmg.gscancer@att.net;3. Center for Molecular Medicine and Immunology , Mendham, New Jersey, USA |
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| Abstract: | ABSTRACT Introduction We describe a new, third-generation of antibody-drug conjugates (ADCs) having a high drug payload against topoisomerase I, important for DNA function, and targeting selective tumor antigens, predominantly TROP-2. |
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| Keywords: | Antibody-drug conjugate camptothecin SN-38 topoisomerase I TROP-2 triple-negative breast cancer monoclonal antibody |
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