| 榄香烯乳剂联合化疗治疗晚期非小细胞肺癌的临床观察 |
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| 引用本文： | 田力,曹悦鞍,彭朝胜,王玮,龙南展.榄香烯乳剂联合化疗治疗晚期非小细胞肺癌的临床观察[J].中国临床医学,2009,16(5):725-727. |
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| 作者姓名： | 田力 曹悦鞍 彭朝胜 王玮 龙南展 |
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| 作者单位： | 海军总医院干三科,北京,100048 |
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| 摘 要： | 目的：观察榄香烯乳剂联合化疗治疗晚期非小细胞肺癌的疗效与安全性。方法：将62例晚期非小细胞肺癌患者随机分为A组（榄香烯注射液＋化疗,32例）和B组（单纯化疗30例）;比较两组治疗前后肿瘤病灶、生活质量、T细胞亚群、血清癌胚抗原（CEA）、糖链抗原-125（CA-125）水平和不良反应发生情况。结果：2周期治疗结束后,A组生活质量评分较B组明显改善（P〈0.05）、A组有效率（31.25%）较B组（26.67%）明显升高（P〈0.05）;A组治疗后较治疗前CD3＋、CD4＋细胞、CD4＋/CD8＋比值升高（P〈0.01）;CD8＋细胞明显下降。而B组治疗后患者CD3＋、CD4＋细胞、CD4＋/CD8＋比值较治疗前降低（P〈0.05）;CD8＋细胞升高,但无统计学差异。与治疗后B组相比,A组血清CEA、CA-125明显减低,（P〈0.01）;B组治疗后CEA、CA-125也较治疗前减低,但无统计学差异。不良反应A组较B组减轻。结论：榄香烯注射液联合化疗可改善晚期非小细胞肺癌患者的生活质量,提高疗效。
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| 关 键 词： | 非小细胞肺癌 榄香烯乳剂 化疗 T淋巴细胞亚群 |
Elemene Emulsion Combined with Chemotherapy in the Treatment of Patients with Advanced Non-small Cell Lung Cancer |
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| TIAN Li,CAO Yuean,PENG Chaosheng,WANG Wei,LONG Nanzhan.Elemene Emulsion Combined with Chemotherapy in the Treatment of Patients with Advanced Non-small Cell Lung Cancer[J].Chinese Journal Of Clinical Medicine,2009,16(5):725-727. |
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| Authors: | TIAN Li CAO Yuean PENG Chaosheng WANG Wei LONG Nanzhan |
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| Institution: | TIAN Li CAO Yuean PENG Chaosheng WANG Wei LONG Nanzhan Department of the Third Cadre Ward,Navy General Hospital,Beijing 100048,China |
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| Abstract: | Objective:To observe the effects of elemene emulsion combined with chemotherapy in treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods:The clinical data of 62 patients with advanced NSCLC from March 2005 to June 2007 were randomly assigned into Group A (32 cases,were treated with combined method) and Group B were treated with chemotherapy only.The tumor size,life quality,T lymphocyte sub-group lever,serum CEA,CA-125 level and side effects were observed before and after treatment in... |
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| Keywords: | Non-small cell lung cancer Elemene emulsion Chemotherapy T lymphocyte sub-group |
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