生物蛋白胶在椎体后凸成形术中应用的离体研究

目的：通过注射骨水泥之前往椎体空腔内注射生物蛋白胶,观察及研究生物蛋白胶能否在椎体空腔中形成一层薄膜,并研究其在后凸成形术中能否减少骨水泥渗漏。方法：取L1-L4椎体,将其随机设为实验组及对照组。按照后凸成形术的方法在椎体内形成空腔,在实验组中先往空腔内注入生物蛋白胶然后再注入骨水泥;而在对照组中直接往空腔内注入骨水泥。比较两组标本的骨水泥渗漏情况。结果：在影像学上,实验组的骨水泥渗漏率较对照组低,且两者差异有统计学意义。在解剖上,椎体空腔内看见一层薄膜,介于椎体骨质与骨水泥之间,包围在骨水泥的周围。在病理上,可见渗漏骨水泥的周围亦有生物蛋白胶包围和保护。结论：生物蛋白胶能在空腔中形成一层薄膜,能够增加骨水泥遭受的阻力及降低其后续流动的范围。

In vitro Study of Fibrin Sealant Applying in the Percutaneous Kyphoplasty

Objective： To observe and study whether the sealant could form a layer of film in the cavity and whether it could reduce the cement leakage in the percutaneous kyphoplasty by means of injecting the sealant into the cavity before the cement injection. Methods：Vertebral body from L1 to L4 were chosen in this experiment and divided into two groups at random. The cavity was created in the vertebral body by the means of percutaneous kyphoplasty. In the experimental group, the sealant was injected into the cavity before the cement. But the cement was injected into the cavity directly in the control group. After that, the cement leakage was compared between two groups. Results： On the X -ray, thc leakage rate in the EP is less than that in the CP. And it has significant difference statistically. Anatomically, a layer of film could be seen between the cement and bone in the cavity. Pathologically, a layer of film also could be seen around the cement. Conclusion：Fibrin sealant could form a layer of film in the cavity. It could increase the force of resistance and decrease the range of subsequent of cement.