| 五脂氧化酶激活蛋白基因多态性及冠心病易患风险 |
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| 引用本文： | 张春燕,郭玮,吴炯,崔俊华,戴谦,宋斌斌,潘柏申.五脂氧化酶激活蛋白基因多态性及冠心病易患风险[J].中国临床医学,2010,17(5):631-634. |
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| 作者姓名： | 张春燕 郭玮 吴炯 崔俊华 戴谦 宋斌斌 潘柏申 |
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| 作者单位： | 复旦大学附属中山医院检验科,上海,200032 |
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| 基金项目： | 上海市科学技术委员会资助项目(编号:08411960400)部分资助;复旦大学附属中山医院青年基金资助 |
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| 摘 要： | 目的：探讨五脂氧化酶激活蛋白基因（-5lipoxygenase activating protein gene,ALOX5AP）突变与冠心病的关系。方法：采用高分辨率溶解曲线法（high resolution melting,HRM）分析150例冠心病患者和280例健康对照者ALOX5AP基因的单核苷酸多态性（SNPs）。结果：ALOX5AP的A22879C位点的CC基因型增加了冠心病3.691倍患病风险;T8733A位点的AA基因型增加了冠心病2.718倍患病风险;T8733A位点的TA杂合基因型增加了冠心病2.962倍患病风险。结论：ALOX5AP的A22879C位点和T8733A位点多态性是冠心病的易患风险因素。
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| 关 键 词： | 五脂氧化酶激活蛋白基因 高分辨率溶解曲线法 冠心病 |
Polymorphism in ALOX5AP Gene and the Risk for Coronary Heart Disease |
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| ZHANG Chunyan,GUO Wei,WU Jiong,CUI Junhua,DAI Qian,SONG Binbin,PAN Baishen.Polymorphism in ALOX5AP Gene and the Risk for Coronary Heart Disease[J].Chinese Journal Of Clinical Medicine,2010,17(5):631-634. |
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| Authors: | ZHANG Chunyan GUO Wei WU Jiong CUI Junhua DAI Qian SONG Binbin PAN Baishen |
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| Institution: | Department of Clinical Laboratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China |
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| Abstract: | Objective：The aim of the present study was to investigate the association between the polymorphism in ALOX5AP gene and the risk for coronary heart disease.Methods： We analysised the polymorphism in ALOX5AP by using of high resolution melting（HRM） to genotype in 150 patients with coronary heart disease and 280 healthy controls.Results： CC in A22879C,AA and TA in T8733A increased the risk of coronary heart disease with an odds ratio of 2.691,2.718 and 2.962,respectively.Conclusions： Polymorphism in ALOX5AP gene is an independent and significant predictor of coronary heart disease. |
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| Keywords: | ALOX5AP High resolution melting Coronary heart disease |
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