Departments of Neurology, Hvidovre Hospital and Rigshospitalet, and Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark
Abstract:
Abstract . The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of l-14C]L-dopa and 3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbi-dopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient ( P ) was calculated to 0.9×10-5 cm s-1.