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Blood-brain barrier permeability of L-dopa in man
Authors:M L FRII  O B PAULSON  M M HERTZ  T G BOLWIG
Institution:Departments of Neurology, Hvidovre Hospital and Rigshospitalet, and Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark
Abstract:Abstract . The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of l-14C]L-dopa and 3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbi-dopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient ( P ) was calculated to 0.9×10-5 cm s-1.
Keywords:Blood-brain barrier  capillary permeability  indicator dilution method  amino acid transport  L-dopa  L-dopa decarboxylase inhibition  man  cerebral blood flow
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