2型糖尿病患者抑郁状况调查及危险因素分析

目的了解2型糖尿病患者抑郁情绪状况并对相关因素进行分析。方法采用Zung抑郁自评量表对247例2型糖尿病患者进行横断面调查,评价抑郁患病率及抑郁程度,并对性别、年龄、职业、文化水平、收入状况、体重指数、病程、降糖方案、血糖、高血压、血脂异常、并发症等因素对抑郁患病率和评分的影响进行比较和相关性分析。结果 2型糖尿病患者的抑郁评分35.58±10.44,患病率为49.8%,显著高于对照组人群的31.04±7.31和8.5%（P〈0.01）。年龄亚组分析显示,40~49岁组抑郁评分为44.20±7.33,患病率高达86.67%,均显著高于其他年龄组患者（P〈0.05）。在职脑力及在职体力患者抑郁评分和患病率均明显高于退休人群（P〈0.05）。口服降糖药及联合胰岛素治疗组患者抑郁评分及患病率均显著高于生活干预组（P〈0.05）。回归分析显示,年龄和慢性并发症是抑郁的独立危险因素。Pearson相关性分析显示,血糖控制差的患者以及伴高血压和慢性并发症的患者抑郁状况更为严重。结论 2型糖尿病患者存在明显的抑郁情绪,中年、在职、血糖控制差、伴高血压及并发症患者抑郁评分及患病率升高更加明显。

Survey of depression status in patients with type 2 diabetes mellitus and analysis of risk factors

Objective To understand the depression status of patients with type 2 diabetes mellitus and analyze the risk factors.Methods A total of 247 patients with type 2 diabetes mellitus were inquired（crosssection study） and assessed with Zung self-rating depression scale（SDS）for depression prevalence and depression severity.Meanwhile,effects of gender,age,occupation,education,income,body weight index（BMI）,disease duration,treatment,glucose control,blood glucose level,hypertension,dyslipidemia and complications on depression prevalence and score were investigated and compared,and their correlations were analyzed.Results The prevalence of depression（49.8%） and the score of SDS（35.58±10.44） in the patients with type 2 diabetes mellitus were higher than those of the control group（31.04±7.31 and 8.5%,P=0.000 and P=0.000）.The scores of SDS（44.20±7.33） and prevalence（86.67%） in the patients aged 40-49 years old were higher than those of other age groups significantly（P0.05）.Depressive status in in-service brainwork and physical work patients was more severe than that in retired population（P0.05）.The SDS scores and depression rate in anti-diabetic drug group and combination therapy group were higher than those in lifestyle intervention group（P0.05）.Age and chronic diabetic complications were independent risk factors of depression based on regression analysis.Patients with poor glucose control,hypertension and chronic complications were more severe in depression status according to Pearson correlation analysis.Conclusion Depression can be easily observed in patients with type 2 diabetes mellitus.The individuals who are middle-aged,on the job,with poor blood glucose control,hypertension and chronic complications are more prone to be depressive.