血清同型半胱氨酸对急性心肌梗死的评估和预测价值

目的探讨血清同型半胱氨酸（homocysteine，HCY）对急性心肌梗死（acute myocardial infarction，AMI）的评估和预测价值。方法收集92例本院心血管内科住院的AMI患者（AMI组），同期60例心血管内科门诊随访体检者作为对照（对照组）。采用高频超声检测两组双侧颈动脉内膜中层厚度（IMT）、粥样斑块及其稳定性，测定HCY水平，并进行分析比较。结果①AMI组颈动脉斑块发生率高于对照组（P〈0．05），不稳定性斑块发生率及血清HCY水平显著高于对照组（P〈0．01）。②HCY与斑块性质之间具有很强的关联性（r=0．975）。结论血清HCY水平检测评估和预测AMI的价值可能更高于颈动脉不稳定性斑块的检出。

The evaluation and prediction values of serum homocysteine for patients with acute myocardial infarction

Objective To evaluate the relationship between serum levels of homocysteine（HCT） and acute myocardial infarction （AMI）. Methods Ninety-two hospitalized AMI patients were designed as AMI group and 60 followed-up cases in out-patient clinic of cardiovascular medicine were used as control group. Carotid IMT and plaque stabilization were assessed by high frequency uhrasonography. Serum levels of HCY were measured. Results ①The incidence rate of plaque in the AMI group was higher than that in the control group（ P 〈 0. 05 ）. The incidence of unstable plaque and the serum HCY level in the AMI group were significantly higher than that in the control group（P 〈 0. 01 ）. ② The serum level of HCY was correlated with stabilization of carotid atherosclerotic plaque（ r = 0. 975 ）. Conclusion The clinical value of HCY level for AMI may be possibly higher than that of the presence of carotid atheroscle- rotic unstable plaques for AMI.