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连续性血液净化对急性重症胰腺炎早期诱导的肠黏膜屏障功能障碍的影响
引用本文:张剑彬,甘华,闵小英,周颖,罗香凤,徐乐,蒋志敏,郭志勇,刘飞燕.连续性血液净化对急性重症胰腺炎早期诱导的肠黏膜屏障功能障碍的影响[J].中国血液净化,2011,10(4):181-184.
作者姓名:张剑彬  甘华  闵小英  周颖  罗香凤  徐乐  蒋志敏  郭志勇  刘飞燕
作者单位:1. 南昌大学第三附属医院肾病风湿科,南昌,330008
2. 重庆医科大学附属第一医院肾内科,重庆,400016
摘    要:目的 研究连续性血液净化(continuous blood purification,CBP)对急性蕈症胰腺炎(severe acute pancreatitis,SAP)早期诱导的肠黏膜屏障功能障碍的作用.方法以26例行持续静静脉血液滤过(continuous veno-venous hemofiltration,C...

关 键 词:急性重症胰腺炎  持续静静脉血液滤过  二胺氧化酶  D-乳酸  跨上皮细胞电阻  上皮细胞骨架蛋白

Effects of continuous blood purification therapy on early induced gut mucosal dysfunction in patients with severe acute pancreatitis
ZHANG Jian-bin,GAN Hua,MIN Xiao-ying,ZHOU Ying,LUO Xiang-feng,XU Le,JIANG Zhi-min,GUO Zhi-yong,LIU Fei-yan.Effects of continuous blood purification therapy on early induced gut mucosal dysfunction in patients with severe acute pancreatitis[J].Chinese Journal of Blood Purification,2011,10(4):181-184.
Authors:ZHANG Jian-bin  GAN Hua  MIN Xiao-ying  ZHOU Ying  LUO Xiang-feng  XU Le  JIANG Zhi-min  GUO Zhi-yong  LIU Fei-yan
Institution:ZHANG Jian-bin1,GAN Hua2,MIN Xiao-ying1,ZHOU Ying1,LUO Xiang-feng1,XU Le1,JIANG Zhi-min1,GUO Zhi-yong1,LIU Fei-yan. 1Department of Nephrology and Rheumatology,the Third Affiliated Hospital of Nanchang University,Nanchang 330008,China,2Department of Nephrology,the First Affiliated Hospital of Chongqing University of Medical Science,Chongqing 400016
Abstract:Objective Early gut mucosal dysfunction is one of the critical pathophysiological disorders in patients with severe acute pancreatitis(SAP).To investigate the effects of continuous blood purification on SAP induced gut mucosal dysfunction,we conducted a prospective study in 26 patients with SAP.Method All patients were treated with continuous veno-venous hemofiltration(CVVH) for 24 hours.Permeability of the epithelial monolayer,serum concentrations of diamine oxidase(DAO),D-lactate and endotoxin were used a...
Keywords:Severe acute pancreatitis  Continuous veno-venous hemofiltration  DAO  D-lactate  Trans-epithelial electrical resistance  F-actin  
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