| MMP-2和TIMP-2对结核性和恶性胸腔积液鉴别诊断价值 |
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| 引用本文： | 唐炳俭,程兆忠,韩伟忠,王丽君,佟丽,孙妮娜.MMP-2和TIMP-2对结核性和恶性胸腔积液鉴别诊断价值[J].康复与疗养杂志,2009(4):335-337. |
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| 作者姓名： | 唐炳俭 程兆忠 韩伟忠 王丽君 佟丽 孙妮娜 |
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| 作者单位： | 青岛大学医学院附属医院呼吸内科,山东青岛266003 |
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| 摘 要： | 目的探讨胸腔积液中基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶组织抑制因子-2（TIMP-2）水平对结核性胸腔积液及恶性胸腔积液的鉴别诊断价值。方法采用ELISA法，检测34例结核性胸腔积液、35例肺部肿瘤并胸腔积液病人胸腔积液中MMP-2和TIMP-2水平，并进行比较。结果恶性胸腔积液组MMP-2和TIMP-2水平均明显高于结核性胸腔积液组，差异有显著性（t=7．099、8．515，P〈0．01）。两组MMP-2／TIMP-2比值差异无显著性（P〉0．05）。诊断特异度与灵敏度TIMP-2均大于MMP-2。结论MMP2和TIMP2可以作为结核性胸腔积液和恶性胸腔积液的鉴别诊断标志。
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| 关 键 词： | 明胶酶A 基质金属蛋白酶组织抑制因子2 胸腔积液 结核 肺肿瘤 |
THE VALUE OF MATRIX METALLOPROTEINASE 2 AND TISSUE INHIBITOR OF METALLOPROTEINASE 2 IN DIFFERENTIAL DIAGNOSIS BETWEEN TUBERCULOUS AND MALIGNANT PLEURAL EFFUSION |
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| Institution: | TANG BINC-JIAN, CHENG ZHAO- ZHONG, HAN WEI-ZHONG, et al (Department of Respirology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China) |
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| Abstract: | Objective To assess the value of of matrix metalloproteinase 2 （MMP 2） and tissue inhibitor of metalloproteinase 2 （TIMP-2） in differentiating tuberculous from malignant pleural effusion. Methods Using ELISA, the levels of MMP- 2 and TIMP 2 in pleural effusion in 34 patients with tuberculous pleural effusion and 35 with malignant pleura1 effusion were detec ted and compared. Results The MMP-2 and TIMP-2 levels in malignant pleural fluid were markedly higher than that in tuberculous plenral fluid, with a significant difference between them （t=7. 099,8.515; P〈0.01）, while the difference of MMP-2/TIMP- 2 ratio was not significant （P〉0.05）. The sensitivity and specificity of TIMP 2 were higher than that of MMP-2. Conclusion MMP-2 and TIMP -2 can be used as differential diagnostic markers in tuberculous pleural effusion and malignant pleural effusion. |
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| Keywords: | Gelatinase A Tissue inhibitor of metalloproteinase 2 Pleural effusions Tuberculosis Lung neoplasms |
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