| 侧脑室注射S100A4蛋白对局灶性脑梗死大鼠神经功能及脑内S100B表达的影响 |
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| 引用本文： | 方征宇,黄晓琳.侧脑室注射S100A4蛋白对局灶性脑梗死大鼠神经功能及脑内S100B表达的影响[J].中国康复,2011,18(6):403-405. |
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| 作者姓名： | 方征宇 黄晓琳 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院康复医学科,武汉,430030 |
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| 摘 要： | 目的：观察经侧脑室注射S100A4蛋白对脑梗死大鼠神经功能以及脑内S100B蛋白表达的影响。方法：36只健康成年SD大鼠线栓法成功复制大鼠大脑中动脉闭塞模型（MCA0），随机分为A、B组各18只，术后第1天A组侧脑室行人工脑脊液注射；B组行S100A4蛋白注射。在MACO术后第1、7及14d时各组各取6只行神经行为学评分，免疫组织化学法检测脑内S100B蛋白的表达情况。结果：B组大鼠在术后第7，14天时神经行为学评分与术后第1天比较有明显下降（1．96±0．49、1．75±0．40与2．94±0．72，P〈0．05），并低于相同时间点A组大鼠。S100B阳性细胞数在术后第7天2组脑内达到峰值，以后开始减少，2组间比较，B组少于A组（P〈0．05）。结论：侧脑室注射S100A4蛋白可一定程度改善脑梗死大鼠神经行为学功能缺损，减少S100B蛋白在脑内的表达。
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| 关 键 词： | S100A4 脑梗死 S100B 大鼠 |
Effects of Injecting S100A4 Protein into Lateral Ventricles on Neural Function and Expression of S100B in Rats with Local Cerebral Infarction |
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| FANG Zheng-yu,HUANG Xiao-lin.Effects of Injecting S100A4 Protein into Lateral Ventricles on Neural Function and Expression of S100B in Rats with Local Cerebral Infarction[J].Chinese Journal of Rehabilitation,2011,18(6):403-405. |
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| Authors: | FANG Zheng-yu HUANG Xiao-lin |
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| Institution: | FANG Zheng-yu,HUANG Xiao-lin.Department of Rehabilitation Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective : To observe the effects of injecting S100A4 into the lateral ventricles on neural function and expression of S100B in rats with cerebral infarction.Methods: Thirty-six Sprague Dawley(SD) rats were randomly divided into two groups: artificial cerebrospinal fluid(aCSF) group(18 rats) and S100A4 protein group(18 rats).The animal model was made by occluding middle cerebra artery.Behavior scores of each group were recorded on the 1st,7th,and 14th day after operation.Immunohistochemical technique was u... |
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| Keywords: | S100A4 cerebral infarction S100B rat |
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