脑梗死血清MMP-3与MMP-9 的动态变化及临床意义

目的：观察血清基质金属蛋白酶3（MMP-3）与基质金属蛋白酶9（MMP-9）在脑梗死患者不同时期的动态变化，探讨其临床意义.方法：62例脑梗死和腔隙性脑梗死患者分别分为观察组1和2，30例健康体检者为对照组，分别检测观察组发病2-5 d、15 d及对照组的血清 MMP-3、MMP-9的含量及神经功能缺损程度评分（CNFDS）。结果：血清MMP-9和MMP-3水平发病2-5 d时,观察组1、2与对照组比较均显著升高（P〈0.01），观察组1 MMP-9水平比观察组2升高更显著（P〈0.01）；发病15 d时,观察组1、2 MMP-9和 MMP-3水平与对照组比较差异无显著性意义。发病2-5 d的血清MMP-9和MMP-3水平与预后呈负相关。结论：脑梗死发病早期血清MMP-9与MMP-3水平的高低与临床病程有关，而且是判断脑梗死近期预后的重要指标。

Dynamic Changes and Clinical Significance of Serum MMP-3 and MMP-9 in Patients with Cerebral Infarction

Objective: To investigate the dynamic changes and clinical significance of serum matrix metalloproteinase-3(MMP-3) and matrix metalloproteinase-9(MMP-9) on various stages in patients with cerebral infarction.Methods: 62 cerebral infarction and lacunar infarction patients were divided into the observation group one and the observation group two,while 30 healthy people served as the control group.Serum MMP-3 and MMP-9 levels and the scores of the Clinical Neurological Function Deficient(CNFDS) were measured during the onset 2 to 5 days and 15 days in the observation group and the control group.Results: The levels of serum MMP-9 and MMP-3 during 2 to 5 days of the cerebral infarction were higher than those in the control group(P<0.01).The serum MMP-9 levels in the observation group one were significantly higher than those in the observation group two(P<0.01).The levels of serum MMP-3 and MMP-9 at the onset 15 days of the observation groups had no significant difference compared with those of the control group.Correlation analysis showed that there was a negative correlation between MMP-9,MMP-3 and prognosis.Conclusion: MMP-3 and MMP-9 may contribute to the pathologic course in the early stage of cerebral infarction.The levels of MMP-3 and MMP-9 are correlated with the clinical course of the disease and prognosis.