小剂量肝素治疗重度子痫前期临床效果及对血清IL-10含量的影响

目的 探讨小剂量肝素对重度子痫前期治疗效果及对孕妇血清白细胞介素10(IL-10)水平的影响.方法 选择我院收治的重度子痫前期40例,随机分为治疗组和对照组,每组20例.对照组予5%葡萄糖注射液1000 ml+25%硫酸镁60 ml,每日1次维持静脉滴注;治疗组在此基础上加用肝素25 mg,每日1次维持静脉滴注6～8 h.监测两组平均动脉压、尿量、红细胞压积、产后出血及孕产妇、新生儿预后,并监测两组孕妇血清IL-10的含量.结果 治疗后两组平均动脉压、红细胞压积、尿量均较治疗前明显改善,差异均有统计学意义(P＜0.05),治疗组各指标改善情况优于对照组,差异均有统计学意义(P＜0.05).两组产后出血、新生儿Apgar评分0～3分及孕周延长致35周以上分娩的发生率比较差异无统计学意义(P＞0.05),治疗组新生儿Apgar评分4～7分发生率为10%,对照组为30%,差异有统计学意义(P＜0.05).治疗组治疗前后IL-10分别为(3.8±1.1)pg/ml、(5.7±0.7)pg/ml,对照组分别为(3.9±0.9 )pg/ml、(4.0±0.7)pg/ml.两组治疗前比较差异无统计学意义(P＞0.05);治疗后治疗组IL-10明显高于治疗前及对照组,差异均有统计学意义(P＜0.05);对照组治疗后血清IL-10含量升高,但与治疗前比较差异无统计学意义 (P＞0.05).结论 小剂量肝素治疗重度子痫前期能升高血清IL-10含量,提示肝素能通过抑制炎性反应达到治疗重度子痫前期的作用.

Clinical Effect of Low-dose Heparin in Treatment of Patients with Severe Pre-eclampsia and Its Influence on IL-10 in Serum

Objective To discuss the clinical effects of low-dose heparin in the treatment of patients with severe pre-eclampsia and its influence on IL-10 in serum.Methods 40 patients with severe pre-eclampsia in our hospital were randomly divided into treatment group and control group with 20 patients in each group.The control group received 5% glucose injection(1000 ml) +25% magnesium sulfate(60 ml),and were kept to intravenous infusion once a day;the treatment group was added with heparin 25 mg based on the treatme...