胃肠胰腺内分泌肿瘤

胃肠胰腺内分泌肿瘤是一类较罕见的、临床表现复杂多术且恶性程度很高的肿瘤，包括胃泌素瘤、胰岛细胞ＶＩＰ瘤、生长抑素瘤、无功能性胰岛细胞瘤、家族性多发性内分泌腺瘤等。此类肿瘤具有某些共同的生化特性，均含有神经内分泌细胞标志物，如神经元特异性烯醇酶、铬粒素、突触素等；它们中约一关以上能产生多种肽类激素，不少病例属于家族性内分泌腺瘤病（ＭＥＮ），遗传外显率很高。除此之外，它们各自还具有独特的生化特性、内镜

Endocrine Neoplasia of Pancreas in Gastrointestinal Tract

Endocrine neoplasia of pancreas in gastrointestinal tract are a rare type of tumors with complex manifestations and high malignancy. They include gastroma, islet Vipoma, somatostatinoma, non-functional islet cell tumor, familial multiple endocrine neoplasia and so on. This type of neoplasia have some common features in biochemistry, that is, they all contain neuroendocrine markers in cytoplasm, for instance, neuro-specific endolase, chromograin and synaptophysin. Polypeptide hormones are produced in more than a half of these neoplasia. And quite a few cases belong to multiple endocrine neoplasia (MEN) with high penetrance of genes. Besides, each of tumors in this caegory has its own unique biochemical characeristics, endoscopic appearence, X-ray findings, laboratory testings. Therefore, threatment protocol should be based on the above features. The prognosis varies with the location, types, size of the primary neoplasia and metastasis. And radical operation is also of significance to the prognosis.