高尿酸血症对血压水平及高血压患病率的影响

目的研究高尿酸血症对血压水平及高血压患病率的影响。方法对体检检出5 058例高尿酸血症及性别相同、年龄相同或相近的5058例非高尿酸血症进行分析,探讨其对血压水平、高血压患病率的影响及与多种心血管危险因素的关系。结果高尿酸血症组收缩压、舒张压分别较对照组升高4 mm Hg和3 mm Hg,高血压患病率为41.9%(95%C I:40.5%~43.3%),显著高于对照组31.3%(95%C I:30.0%~32.6%),差异有统计学意义。高尿酸血症组肥胖、高胆固醇血症及高三酰甘油血症患病率均高于对照组,差异有统计学意义。高尿酸血症、男性、年龄增长、肥胖、糖尿病、高胆固醇血症和高三酰甘油血症是高血压的独立危险因素。结论高尿酸血症与较高的血压水平有关,可能是高血压患病率增加的独立危险因素。

The effects of hyperuricemia on the level of blood pressure and the prevalence of hypertension

Objective To study the effects of hyperuricemia on the level of blood pressure and the prevalence of hypertension.Methods 5,058 patients who were confirmed to be hyperuricemia in the Health Center of Anhui Provincial Hospital from January 2005 to December 2007 were enrolled to be the case group.Another 5058 people whose serum uric acid（SUA） were normal in the same health examination were selected and matched with the case group by sex and age to be the control group.SUA,total cholesterol（TC）,triglycerides（TG）,fasting blood glucose（FBG） and blood pressure were detected.Then the relationship of hyperuricemia and the prevalence of hypertension were analyzed.Results The mean systolic blood pressure,diastolic blood pressure in the case group were significantly higher than that in the control group（P=0.000） by 4 mm Hg and 3 mm Hg,respectively.The prevalences of hypertension,obesity,hypercholesterolemia,hypertriglyceridemia were also significant higher than those in the control group（P=0.000）.Hyperuricemia,male,age,obesity,diabetes,hypercholesterolemia and hypertriglyceridemia were main risk factors for hypertension.Conclusions Hyperuricemia is associated with higher blood pressure and may be one of independent risk factors for hypertension.