18-氟-脱氧葡萄糖PET/CT双时相显像在孤立肺结节中的诊断价值

目的探讨18F-FDG PET双时相显像在孤立肺结节中的定性诊断价值。方法住院或门诊患者,经CT证实符合孤立性肺结节病例30例,男18例,女12例,平均年龄(52.3±6.2)岁,应用PET/CT检查技术对孤立性肺结节病例进行双时相显像,首次显像于注射FDG后40~65 min,延迟显像于注射后1.5~2.5 h进行,测定两次显像病灶的标准摄取值(SUV),并计算两次显像SUV变化率。结果30例孤立肺结节病理证实恶性病变17例,良性病变13例。肺癌组患者早期SUV 4.21±1.71,延迟显像为5.98±2.32,SUV变化率为(41.9±7.81)%。良性病变组患者早期SUV 2.71±1.62,延迟显像为3.17±1.13,SUV变化率为(16.97±5.62)%。结论18F-FDG PET-CT双时相显像方法简便,在临床上具有一定的实用价值,肺恶性病变延迟显像SUV升高的幅度高于良性病变。

Role of 18F-FDG PET/CT dual time point imaging in the diagnosis of solitary pulmonary nodule

Objective To evaluate the role of dual time point ^18F-FDG PET/CT imaging in the diagnosis of solitary pulmonary nodule. Methods 30 patients with solitary pulmonary nodule demonstrated by CT, male 18 patients, female 12 patients, mean age （52.3 ± 6.2） year old. All these patients underwent dual time point lS F-FDG PET/CT imaging. The imaging protocol included the early imaging of PET/CT at 40-65 minutes and delayed imaging of PET at 1.5-2.5 hours post injection ^18F-FDG. The standardized uptake value（SUV） was calculated for both time points. All results were expressed as the percentage change in SUV. Results Histopathology demonstrated 17 patients with malignant lesions and 13 patients with benign lesions. The SUV of malignant lesions was SUV 4.21 ± 1.71 of early imaging and 5.98 ±2.32 of delayed imaging. The increasing rate of malignant lesions was （41.9 ±7.81 ）%. The SUV of benign lesions was 2.71 ± 1.62 of early imaging and 3.17 ± 1.13 of delayed imaging. The increasing rate of benign lesions was （16.97 ± 5.62）%. Conslusions Dual time point imaging is a simple and practical method for the detection of malignant lung lesions. The prelimary data suggest that malignant nodules have a greater rise of SUV in the delayed imaging as compared to benign nodules.