长期家庭氧疗对慢性阻塞性肺病急性加重期病情的影响

目的观察长期家庭氧疗对慢性阻塞性肺病(COPD)患者急性加重期病情及疗效的影响。方法54例COPD急性加重期患者,其中28例为氧疗组,至少经过6个月以上的家庭氧疗,氧流量1~2 L/m in,吸氧时间(12.3±4.6)h/d,26例为对照组。比较两组患者咳嗽、咳痰、喘息及肺部哮鸣音评分、肺功能测定、血气分析、细胞免疫功能,并观察两组治疗1周后达到临床症状显著控制率。结果(1)急性加重期时,氧疗组咳嗽、咳痰、喘息、肺部哮鸣音评分较对照组低(P<0.05);(2)氧疗组氧分压(PaO2)、CD3+、CD4+、CD4+/CD8+较对照组高(P<0.05);(3)治疗1周后,氧疗组达到临床症状显著控制率较对照组高(P<0.05)。结论长期家庭氧疗可明显减轻COPD急性加重期患者的临床症状及缩短疗程,可能与氧疗患者细胞免疫功能升高、部分纠正低氧血症有关。

The effect of long-term domicilinary axygen therapy on the patients' condition of chronic obstructive pulmonary disease during the acute exacerbation period

Objective To observe the patients' condition and treatment in chronic obstructive pulmonary disease(COPD) acute exacerbation influenced by long-term domicilinary oxygen therapy(LTDOT).Methods Fifty-four cases with COPD in acute exacerbation were divided into two groups,twenty-eight cases as oxygen-therapy group with oxygen flow of 1～2 L/min for average(12.3±4.6) hours every day for more than six months.Clinical symptoms including cough、sputum、dyspnea and sibilant、the lung function test、 analysis of artery blood-gas、the condition of cellular immune function and obtaining clinical symptoms control rate after one week treatment between two groups were compered.Results (1)During the acute exacerbation,Symptoms including cough、sputum、dyspnea and sibilant in oxygen-therapy group were lower than those of control group(P<0.05);(2)PaO_2、NKC activity、CD~+_3、CD~+_4、CD~+_4/CD~+_8 in oxygen-therapy group were higher than those of control group(P<0.05);(3)After one week treatment,control rates of clinical symptoms were higher than those of control group(P(<0.05)).Conclusions LTDOT alleviated significantly the clinical symptoms of patients with COPD during the acute exacerbation and shorted the therapy period.The reason may be related with improvement cellular immune function and partly corrected hypoxaemia in patients by LTDOT.