单核细胞趋化蛋白-1与急性冠状动脉综合征的相关性

目的通过研究急性冠脉综合征(ACS)患者单核细胞趋化蛋白-1(MCP-1)的变化,探讨其与冠脉病变的相关性。方法选取60例ACS患者,包括急性心肌梗死(AMI)患者28例,不稳定型心绞痛(UA)患者32例,心电图无缺血性改变并经冠状动脉造影排除冠心病的胸痛患者为对照组30例,采用酶联免疫法法测定MCP-1,所有ACS患者进行冠状动脉造影对冠脉血管进行损害程度评分,研究MCP-1与冠状动脉狭窄范围及程度的关系。结果①ACS组MCP-1组明显高于对照组(152.27±34.24)pg/ml vs(113.45±21.98)pg/ml,P<0.01]。②ACS组内血清MCP-1水平在AMI组与UA组间差异无统计学意义(153.46±18.67)pg/ml vs(150.16±22.45)pg/ml,P>0.05]③冠状动脉狭窄程度积分在ACS组内UA组与AMI组比较差异无统计学意义(P>0.05),两组内冠状动脉狭窄程度与外周血MCP-1水平均无相关性(P>0.05)。结论外周血MCP-1水平可以判断ACS的严重程度,但与冠状动脉的病变狭窄程度无明显关系。

Clinical study of correlation between MCP-1 and acute coronary syndrome

Objective To explore the relationship between The monocyte chemoattractant protein-1 （MCP-1） and the stenosis degree of the coronary artery in patients with acute coronary syndrome（ACS）. Methods Sixty patients with ACS confirmed by coronary angiography and 30 controls with a chest pain but no ischemic changes in ECG and no coronary heart disease confirmed by coronary angiography were recruited in this study. The level of MCP-1 was measured by ELISA. Results ①The of MCP-1 in patients with ACS was significantly higher than that in controls ;②there were no significance different of MCP-1 ＇ s level between UA and AMI groups（ P 〉 0. 05 ）. ③There was no significant different of culprit coronary artery lesions between UA and AMI groups （ P 〉 0. 05 ）. The level of MCP-1 in periphal blood was no correlated with culprit coronary artery lesions in ACS （P 〉 0. 05）. Conclusion The level of MCP-1 could be an index to indicate the stenosis range and degree of the coronary artery.