声辐射力脉冲弹性成像技术评估肝占位患者肝脏储备功能的临床价值

目的探讨声辐射力脉冲弹性成像（ARFI）技术评估肝占位患者肝脏储备功能的临床价值。方法选择2011年9月至2012年8月解放军总医院86例肝占位患者。其中肝功能Child-PughA级54例，B级18例，C级14例；70例患者进行手术治疗，16例患者采用非手术治疗。采用ARFI技术测量患者肝脏剪切波速度值（SWV）；同时对患者进行吲哚氰绿（ICG）排泄实验，记录ICG血浆清除速率及ICG 15min滞留率。SWV值与ICG血浆清除速率、ICG 15min滞留率的相关性采用Pearson相关分析；SWV值与Child．Pugh分级的相关性采用Spearman等级相关分析。手术治疗患者与非手术治疗患者SWV值比较采用独立样本t检验以患者的临床决策作为金标准，采用受试者操作特性（ROC）曲线评价ARFI技术判断肝占位患者手术可行性的应用价值。结果SWV值与ICG 15min滞留率、ICG血浆清除速率、Child．Pugh分级有相关性（r=0．764，P〈0．001；P0．686，P=-0．000：r=0．864，P=-0．000）。手术治疗患者SWV值为（2．46±0．45）m／s，非手术治疗患者SwV值为（1．54±0．36）m／s，差异有统计学意义（t=-0．80，P=0．000）。ROC曲线显示，当诊断界值为2．06m／s时，约登指数最高为0．775，其相对应的ARFI技术判断肝占位患者手术可行性的敏感度为87．5％，特异度为90．0％。结论ARFI技术可有效评估肝占位患者肝脏储备功能，为临床治疗方式的决策提供帮助。

The clinical value of acoustic radiation force impulse imaging in the assessment ot liver tuncuonat reserve in patients with hepatic focal lesions

Objective To investigate the clinical value of acoustic radiation force impulse （ARFI） imaging in the evaluation of liver functional reserve in patients with hepatic focal lesions. Methods Eighty-six patients with hepatic focal lesions in General Hospital of the People＇s Liberation Army from September 2011 to August 2012 were studied. According to Child-Pugh score, 54 of them were classified as grade A, 18 patients were classified as grade B, and 14 patients were classified as grade C. Seventy patients underwent surgery and 16 patients underwent non-surgical treatment. Shear wave velocity （SWV） values were measured using ARFI technique, and indocyanine green （ICG） clearance tests were also performed to achieve ICG clearance rate constant （ICGK） and ICG retention rate at 15 minutes （ICG15）. Correlation between SWV and ICGK, SWV and ICG15 were studied using Pearson correlation, and correlation between SWV and Child-Pugh score were analyzed using Spearman rank correlation. Difference between SWV values of patients underwent surgery and those of patients underwent non-surgical treatment was compared using t-test for independent samples. Analyses of receiver operating characteristic （ROC） curve were performed to investigate the value of ARFI in the evaluation of surgical feasibility for patients with hepatic focal lesion, with the clinical decisions serving as the golden standard. Results There was correlations between SWV and ICGRIS, SWV and ICGK, and SWV and Child-Pugh scores （r=0.764, P 〈 0.001： r=-0.686, P=0.000. r=0.864, P=0.000）. The SWV of patients who underwent surgery was （2.46±0.45） m/s, and the SWV of patients who underwent non-surgical treatment was （1.54±0.36） m/s, with a significant difference （t=-0.80, P=0.000）. The ROC curve analysis demonstrated a highest Youden＇s index of 0.775 when the cut-off was 2.06m/s. The corresponding sensitivity was 87.5% and the specificity was 90.0% for ARFI in the diagnosis liver functional reserve deficiency. Conclusion ARFI can effectively evaluate the liver functional reserve in patients with hepatic focal lesions and thus could be beneficial in the decision of clinical treatment.