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5种肿瘤标志物检测在卵巢肿瘤的临床意义
引用本文:钟倩,刘婉敏,芦雅萍,练晓勤,张伟健,王海清,刘芳.5种肿瘤标志物检测在卵巢肿瘤的临床意义[J].中国实验诊断学,2010,14(6):876-878.
作者姓名:钟倩  刘婉敏  芦雅萍  练晓勤  张伟健  王海清  刘芳
作者单位:江门市中心医院,妇科,广东,江门,529030
摘    要:目的探讨血清CA125、CA724、CA199、CEA、AFP多种肿瘤标志物在卵巢肿瘤的临床意义与诊断价值。方法采用电化学发光方法检测45例卵巢上皮性癌患者2、1例卵巢恶性生殖细胞肿瘤患者,对照组为15例交界性卵巢上皮类肿瘤患者、56例卵巢良性肿瘤患者(上皮性及生殖性)、76例卵巢巧克力囊肿患者、23例附件脓肿患者血清CA125、CA724、CA199、CEA、AFP水平并进行比较。结果①卵巢癌患者五种肿瘤标志物均高于卵巢良性肿瘤(P0.01),CA125良性肿瘤与交界性肿瘤比较有统计学意义(P0.05),其余四种肿瘤标志物良性肿瘤与交界性肿瘤比较无统计学意义(P0.05)。②仅采用CA724与CA125相比时,则CA724在诊断卵巢癌的特异性高,而CA125灵敏性较高;在恶性卵巢上皮性肿瘤中,CA125在腹水阳性时升高明显,与腹水阴性有统计学意义(P0.05)。③CA199在上皮性粘液性腺癌明显升高,与浆液性腺癌有显著性差异(P0.05);AFP在恶性生殖类肿瘤异常升高,与上皮性恶性肿瘤有显著性差异(P0.05)。结论上述五种肿瘤标志物在诊断卵巢癌都有一定的临床意义。

关 键 词:血清CA125  血清CA724  血清CA199  血清CEA  血清AFP  卵巢肿瘤

The clinical value of serum combined assay CA125、CA724、CA199、CEA、AFP in the diagnosis of ovarian and tubal masses
Institution:ZHONG Qian, LIU Wan-rain, LU Ya-ping , et al . ( The Center Hospital of Jiangmen , Jiangmen 529030, China)
Abstract:Objective to investigate the clinical significance and diagnostic value of detecting different serum tumor makers: CA125,CA724,CA199,CEA,AFP in ovarian tumor. Methods Using eletrochemiluminescence method detecting and comparing five groups serum tumor makers: epithelial cancer of ovary group ( n = 45), malignant germ cell tumor of ovary group ( n = 21 ), ovarian benign tumor group (epithelial tumor and germ cell tumor, n = 56), chocolate cyst of ovary group ( n = 76) ,ovarian and tubal abscess group ( n = 23 ), borderline ( low malignant potential) epithelial tumor ot: ovary group ( n = 15 ). Results (1) The serum levels of five tumor markers in patients with ovarian cancer were higher than in benign ovarian tumors ( P 〈 0.01), The serum CA125 levels were statistically significant in benign ovarian tumors and borderline tumors ( P 〈 0.05), The serum levels of the remaining four kinds of tumor markers were no significant differen in benign ovarian tumors and borderline ovarian tumor ( P 〉 0.05). (2) when comparing CA724 and CA125 only, CA724 has higher specificity in diagnosing ovarian cancer, while CA125 has higher sensitivity. in malignant epithelial ovarian tumors, The serum CA125 levels increased significantly when the positive in the ascites, and were statistical significance negative in ascites (P 〈 0. 05). (3)The levels of CA199 increased in epithelial mucinous cystadenocarcinoma, were significant difference with serous cyst,adenocarcinoma ( P 〈 0.05) ;The levels of AFP increased in malignant ovarian germ ceil tumors, were significant difference in epithelial malignant tumors ( P 〈 0.05). Conclusion The total five serum tumor makers have great clinical significance in diagnosing and evaluating the character of ovarian and tubal masses.
Keywords:CA125  CA724  CA199  CEA  AFP ovarian tumor
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