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| 纳米银/PLGA共聚物复合纤维对大肠埃希菌抑菌作用研究 | |
| 引用本文： | 施雨露,张小楠,刘照轩,曲影,徐效义.纳米银/PLGA共聚物复合纤维对大肠埃希菌抑菌作用研究[J].中国实验诊断学,2013,17(7):1188-1190. |
| 作者姓名： | 施雨露 张小楠 刘照轩 曲影 徐效义 |
| 作者单位： | 1. 吉林大学白求恩医学院病原免疫细胞遗传学实验中心,吉林,长春130021 2. 长春中医药大学药学系,吉林,长春130117 3. 吉林大学第一医院肿瘤中心,吉林,长春130021 |
| 摘 要： | 目的探讨生物降解纳米银/丙交酯-乙交酯共聚物（纳米银/PLGA）复合纤维对大肠埃希菌的抑菌作用。方法应用静电纺丝技术制备纳米银/PLGA复合纤维,通过扫描电镜（SEM）和透射电镜（TEM）研究纤维的形貌以及纳米银的分布;体外实验研究纳米银的释放行为和对大肠埃希菌的抑菌能力。结果纳米银/PLGA复合纤维和银粒子直径分别约为600nm和30nm,随着增加银的浓度,纤维导电性能增强,纳米银在缓冲溶液中持续释放,累积释放量达到ppm级（百万分之）,体外培养12h后,对大肠埃希菌的抑制率为99%。结论综合纳米技术（nanotechnol-ogy）和生物技术（biotechnology）研究手段制备的纳米银/PLGA复合纤维具有强大的抑制大肠埃希菌生长效果,可以用作组织工程支架和体内植入材料。 |
| 关 键 词： | 纳米 复合纤维 生物降解 抑菌作用 银 |
Study of antimicrobial activity of silver nanoparticles and poly(lactide-co-glycolide) composite fiber on escherichia coli |
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| Institution: | S H I Yu-lu , ZHANG Xiao-nan , LIU Zhao-xuan , et al. (1. Experimental center of pathogenic immune cytogenetic , Be- thune Medical College, Jilin University, Changehun 130021, China ; 2. Department of Pharmacy, Chinase Medicine of Changchun University, Changchun 130117, China 3. Cancer center of First Hospital, J ilin University, Changchun 130021, China) |
| Abstract: | Objective To explore the antimicrobial effect of the inhibition of biodegradable nanosilver and Poly（lac- tide-co-glycolide） （nananeter silver／PLGA）composite fiber on Eschericbia coll. Methods Application of electrospin- ning technology to prepare nano-silver/PLGA composite fibers, fiber by scanning electron microscopy （SEM） and transmission electron microscopy （TEM） study morphology and distribution of nano-silver~vitro study the release be- havior of nano-silver and Escherichia coliantibacterial activity. Results Nano silver/PLGA fibers and the diameter of the silver particles is about 600nm and 30 nm,respectively,with increasing concentration of silver fiber conductiye per- formance enhancements, the nano silver sustained release in a buffer solution, and the cumulative release of the ppm lev- el （ppm）cultured for 12 hours in vitro inhibition of E. coli was 99%. Conclusion Integrated Nanotechnologies （nano- technology） and biotechnology （biotechnology） research prepared by means of nano-silver/PLGA composite fibers with a strong inhibition of Escherichia coli growth effect, can be used as tissue engineering scaffolds and implanted materials. |
| Keywords: | Nananeter Composite fiber Biodegradable Antimicrobial Activity silver |
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