肺癌患者血浆纤维蛋白原的检测及其临床意义

目的]通过检测肺癌患者血浆中的纤维蛋白原（FIB）含量，研究肺癌患者FIB与肺癌的病理分型、分化程度、临床分期、以及和转移与否的关系，评价其在肺癌辅助诊断及判断预后的临床意义。方法]使用ACL200血凝分析仪检测277例初诊肺癌患者和37例肺良性疾病患者血浆FIB，之后进行统计学分析。结果]肺癌患者血浆FIB明显高于肺良性疾病患者；鳞状细胞肺癌和其它细胞肺癌FIB明显高于腺癌；临床分期越高，FIB越高；存在转移者明显高于无转移者；分化程度越低，FIB水平越高。结论]肺癌患者存在FIB异常，重症肺癌患者（高临床分期、低分化、远处转移等）血浆FIB升高。通过检测血浆中FIB含量对肺癌的辅助诊断及判断预后可能具有一定的意义。

Detection of plasma fibrinogen in patients with lung carcinoma and its clinical significance

Objective] To investigate the relation of plasma level of fibrinogen to pathological type, differentiation degree, clinical stage and metastasis of lung carcinoma. Methods] The subjects of this study included 277 patients with lung carcinoma in preliminary diagnosis and 37 patients with benign lung diseases. The plasma level of fibrinogen was determined by COULTER ACL -200 automated coagulation analyzer. Results] The plasma level of fibrinogen was higher in the patients with lung carcinoma than in those with benign lung diseases. Meanwhile, it was higher in squamous lung carcinoma than in other types of lung carcinoma. The plasma level of fibrinogen increased when the clinical stage went further. The level was also higher in patients with metastasis or with low differentiation of the carcinoma. Conclusion] Fibrinogen increases in lung carcinoma, especially in the late stage.