乳腺癌患者发生静脉血栓栓塞症危险因素分析

目的 探讨乳腺癌患者发生静脉血栓栓塞症的危险因素.方法 回顾性分析自2014年7月至2020年3月新汶矿业集团莱芜中心医院收治的90例女性乳腺癌患者临床资料,根据静脉血栓栓塞症发生情况分为未发生静脉血栓栓塞症的A组(n=60)与发生静脉血栓栓塞症的B组(n=30).记录两组患者的年龄、体质量指数、糖尿病病史、冠心病病史、高血压病史、绝经状态、经外周静脉穿刺中心静脉置管(PICC)情况、白细胞计数、血小板计数、凝血酶原时间、活化部分促凝血酶原激酶时间、D-二聚体、放疗情况、新辅助化疗、术后化疗、内分泌治疗、病理类型、术式、转移位置、临床分期等临床资料并进行单因素分析,而后采用Logistic回归分析进行多因素分析.结果 两组患者年龄、体质量指数、糖尿病患者比例、行PICC置管患者比例、术后化疗患者比例、白细胞计数、血小板计数比较,差异有统计学意义(P<0.05).年龄、体质量指数、糖尿病、术后化疗、血小板计数为乳腺癌患者发生VTE的独立危险因素(P<0.05).结论 年龄、体质量指数、糖尿病、术后化疗、血小板计数为乳腺癌患者发生静脉血栓栓塞症的独立危险因素.

Risk factors of venous thromboembolism in patients with breast cancer

Objective To investigate the risk factors of venous thromboembolism(VTE)in patients with breast cancer.Methods A retrospective study was performed on 90 cases of female patients with breast cancer who were admitted from July 2014 to March 2020.According to the occurrence of VTE,the patients were divided into two groups:Group A(n=60)without VTE and Group B(n=30)with VTE.The age,body mass index,history of diabetes,coronary heart disease,hypertension,menopausal status,peripherally inserted central catheter(PICC),white blood cell count,platelet count,prothrombin time,activated partial thromboplastin kinase time,D-dimer,radiotherapy,neoadjuvant chemotherapy,postoperative chemotherapy and endocrine therapy were recorded Univariate analysis was used to analyze the clinical data including treatment,pathological type,operation type,location of metastasis and clinical stage,and multivariate analysis was performed by logistic regression analysis.Results There were statistically significant differences in age,body mass index,proportion of diabetes patients,proportion of patients receiving PICC catheterization,proportion of patients receiving postoperative chemotherapy,white blood cell count and platelet count between two groups(P<0.05).Age,body mass index,diabetes mellitus,postoperative chemotherapy and platelet count were independent risk factors for VTE in breast cancer patients(P<0.05).Conclusion Age,body mass index,platelet count,diabetes mellitus and postoperative chemotherapy are independent risk factors for venous thromboembolism in breast cancer patients.