康复训练对脑梗死大鼠中枢神经系统Fos表达的影响

目的 研究康复训练对脑硬死大鼠中枢神经系统Fos蛋白表达的影响。方法 采用60只SD大鼠制作脑梗死模型；1d后随机分为康复组和制动组；康复组每天给予平衡、抓握、旋转、行走等训练，制动组置于网状笼内固定，各组在1、7、14、21、28d检测Fos表达。结果 康复组和组大鼠大脑皮质、丘脑、下丘脑、基底节、网状结构及脊髓后角均出现Fos阳性反应，两组比较差异有非常显著性意义（P＜0．01）。结论 康复训练可激活脑梗死大鼠梗死灶周围和对侧相应皮质神经元功能，促进运动功能恢复。

Effects of rehabilitation training on the expression of Fos in the central nervous system of rats with cerebral infarction

Objective To study the effect of rehabilitation training on the expression of Fos in the central nervous system(CNS) of rats with cerebral infarction. Methods 60 SD rats were made as cerebral infarction models and divided into 2 groups at random 24 hours later: rehabilitation group was given balancing, grasping, rotating and walking and other trainings everyday, while immobiligation group was fixed in cages. Immunohistochemistry was used to detect the Fos expression 1 d, 7 d, 14 d, 21 d and 28 d after infarction respectively. Results Fos positive immune reaction appeared in cortex,thalamus, hypothalamus, reticular form and posterior gray horn of the spinal cord of both groups.Rehabilitation group responded stronger than the immobilization group significantly (P< 0.01 ).Conclusion Rehabilitation training can activate cortical neurons around the infarted focus and in its opposite side of the CNS, and thus promote the recovery of rats' motor functions.