首页 | 本学科首页   官方微博 | 高级检索  
     

磁性生物陶瓷人工椎体靶向治疗椎骨肿瘤的可行性研究与大动物试验
引用本文:娄朝晖,陈安民,吴华,夏劲松,袁松柳,孙淑珍,夏正才,赵明. 磁性生物陶瓷人工椎体靶向治疗椎骨肿瘤的可行性研究与大动物试验[J]. 中华物理医学与康复杂志, 2004, 26(6): 328-332
作者姓名:娄朝晖  陈安民  吴华  夏劲松  袁松柳  孙淑珍  夏正才  赵明
作者单位:[1]华中科技大学同济医学院附属同济医院骨科,武汉,430030 [2]华中科技大学物理系,武汉,430030 [3]武汉理工大学材料工程学院,武汉,430030
基金项目:湖北省科技攻关计划重点项目 (No.2 0 0 1AA30 7B1 0 )
摘    要:目的 研究应用磁性生物陶瓷人工椎体靶向治疗椎骨肿瘤的可行性。方法 选择2~4岁健康山羊4只,椎体切除后行“磁性生物陶瓷人工椎体置换术”。山羊术后于前小腿外侧皮下静脉注射^99MTc4^-标记的葡聚糖磁微粒(DMN)(0.1mg/kg体重),L4区域应用医用磁导向定位仪,磁场强度为1T。ECT采集时间为:给药后0~1min内,每2s采集1次,共30次;此后,在给药后20,40,60,80min各采集1次,动态观察在磁场条件下,^99MTc4^-标记的DMN在靶区的富集情况;同时对心、肝、脾、肾和肺等脏器进行同步ECT采集显像,动态观察DMN在体内的分布情况。结果 在体外磁场的作用下,ECT显像显示给药40min后磁区出现^99MTc4^-标记的DMN富集,且富集的浓度随磁场作用的时间的延长而增高,80min时DMN在磁区的浓集继续增加。撤除外加磁场,DMN浓集随即消失。结论 在外磁场的作用下,具有顺磁性的磁性生物陶瓷的磁化强度升高,产生与体外磁场方向一致的体内小磁场,在体内、外磁场的联合作用下,具有超顺磁性的DMN浓集于磁性生物陶瓷人工椎体区域,可使局部定位更明确、具体,强化有效的靶向治疗效果,即形成“体腔内特定区域的靶向治疗”。

关 键 词:磁性生物陶瓷  人工椎体  靶向治疗  椎骨肿瘤  可行性  大动物试验  葡聚糖磁性微粒

Feasibility of the targeting therapy as applied in the sheep after vertebra replacement with artificial magnetic bioceramic vertebral body
LOU Zhao hui ,CHEN An min,WU Hua,XIA Jing song,YUAN Song liu,SUN Shu zhen,XIA Zheng cai,ZHAO Ming. Feasibility of the targeting therapy as applied in the sheep after vertebra replacement with artificial magnetic bioceramic vertebral body[J]. Chinese Journal of Physical Medicine and Rehabilitation, 2004, 26(6): 328-332
Authors:LOU Zhao hui   CHEN An min  WU Hua  XIA Jing song  YUAN Song liu  SUN Shu zhen  XIA Zheng cai  ZHAO Ming
Affiliation:LOU Zhao hui *,CHEN An min,WU Hua,XIA Jing song,YUAN Song liu,SUN Shu zhen,XIA Zheng cai,ZHAO Ming. *Department of Orthopaedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
Abstract:Objective To study the possibility and effect of the targeting therapy in sheep applied with artificial magnetic bioceramic vertebral body replacement and intravenous injection of the dextran magnetic nanoparticles. Methods Magnetic guidance of 99 M Tc - 4 labeled dextran nanoparticles was evaluated in sheep with the replacement of artificial magnetic bioceramic vertebral body in L 4. The dextran magnetic nanoparticle was administrated by intravenous injection. An outside magnetic field was applied in the back of L 4. The localization of the dextran nanoparticles was determined in vivo by ECT,and the distribution of dextran nanoparticles in liver, lung, spleen, and kidney were also investigated. Results It was shown that the dextran nanoparticles was highly reactive to magnetic field, and concentrated at the predetermined site. The radioactivity accumulation in other organs, especially in liver, was significantly reduced due to the presence of the outside magnetic field. When the magnetic field was removed, the radioactivity accumulation in the back disappeared. Conclusion The magnetic bioceromic has good paramagnetism and its intensity of magnetization could be raised when the extra corporeal magnetic field is applied. As a result, the local magnetic field is reinforced, and its direction is coincident with the extra corporeal magnetic field. Therefore the local reinforced targeting therapy could be formed around the area of the artificial magnetic bioceramic vertebral body when the dextran magnetic nanoparticles were attracted by the double magnetic field and concentrated in the target field.
Keywords:Artificial magnetic bioceramic vertebral body  Targeting therapy  Dextran magnetic nano particle
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中华物理医学与康复杂志》浏览原始摘要信息
点击此处可从《中华物理医学与康复杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号