超短波早期治疗激素性股骨头缺血性坏死的实验研究

目的采用马血清、激素联合应用诱导股骨头坏死模型，观察超短波早期干预治疗的效果。方法对新西兰大白兔联合应用马血清、激素造模处理，30只大白兔随机分成对照组、模型组和超短波组，各组分别检测血栓素A2(thromboxane A2，TXA2)、前列环素(prostaglandin，PGI2)和血脂(triglyceride，TG)、胆固醇(total cholestrol，TCh)及血液流变学指标，并进行分析比较。结果10周后模型组产生股骨头缺血性骨细胞死亡，骨髓细胞减少，出现高粘滞血症、高脂血症和TXA2-PGI2平衡失调，导致血栓形成，造成股骨头缺血性坏死。、而超短波组进行超短波干预治疗后，血液循环加快，血脂水平降低，血液粘度降低，血小板活性下降，TXA2-PGI2平衡得以恢复，从而保护血管内皮，防止血栓形成．结论上述各项指标的检测是激素性股骨头缺血性坏死较为敏感的指标，超短波早期干预治疗可能成为防治激素性股骨头缺血性坏死发生的一种新疗法。

Experimental study of hormone-induced ischemic femoral head necrosis treated with ultrashort wave in early stage

Objective To observe the effectiveness of early intervention with ultrashort wave diathermy in the treatment of experimental avascular necrosis of femoral head (ANFH). Methods Thirty New Zealand white rabbits were divided into three groups:a normal group(group A),a model group(group B) and an ultrashort wave diathermy group(group C). The animals in groups B and C were subject to injection of horse blood serum and methyl prednisolone to induce ANFH, while those in group A were administered with injection of normal saline. The TXA 2, PGI 2, TG, TCh and hemorrheological indice were tested with all the rats. Results The animals in the model group were found with ANFH manifesting avasular necrosis of femoral head bone cells, decrease of bone marrow cells, high blood viscosity and imbalance of TXA 2 PGI 2. The ultrashort wave diathermy group demonstrated significant improvement with regard to the blood supply, the TG level and blood viscosity,as well as the PLT activity and the TXA 2 PGI 2 ratio. Conclusion The ultrashort wave diathermy could be an effective treatment method for preventing ANTH when used in the early stage of development of the condition.