| 高通量测序技术在脓毒症病原微生物检测中的价值 |
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| 作者姓名： | 许娜娜 周敏 尹梅 崔毅 李琛 陈晓梅 丁士芳 翟茜 吴大玮 王昊 |
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| 作者单位： | 1. 250012 济南，山东大学齐鲁医学院
2. 250012 济南，山东大学齐鲁医院重症医学科
3. 250012 济南，山东大学齐鲁医院老年病科 |
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| 基金项目： | 国家自然科学基金(81873927); 中国博士后科学基金面上资助项目(2018M632685); 山东省自然科学基金资助项目(ZR2017PH050) |
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| 摘 要： | 脓毒症是急危重症医学面临的重要临床问题，发病率、病死率居高不下，早期病原微生物诊断对尽早实施目标治疗、降低病死率至关重要。目前的病原微生物检测技术在及时性和准确性等方面仍有欠缺。高通量测序技术一定程度上能够克服传统病原学检测技术的缺点，并正在逐步应用于临床，但目前仍存在一系列问题。本文将对该技术在脓毒症病原微生物检测中的价值及其优缺点作一综述。
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| 关 键 词： | 高通量测序 脓毒症 病原微生物 |
| 收稿时间： | 2018-11-07 |
The value of high-throughput sequencing in the pathogenic detection of sepsis |
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| Authors: | Nana Xu Min Zhou Mei Yin Yi Cui Chen Li Xiaomei Chen Shifang Ding Qian Zhai Dawei Wu Hao Wang |
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| Institution: | 1. Cheeloo College of Medicine, Shandong University, Jinan 250012, China
2. Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
3. Department of Geriatrics, Qilu Hospital of Shandong University, Jinan 250000, China |
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| Abstract: | Sepsis is an important clinical problem in intensive care units, and lead to significant high morbidity and mortality. Early detection of pathogen is crucial for the implementation of targeted treatment and improvement of prognosis. However, the current pathogenic detection techniques are still lack of timeliness and accuracy. High-throughput sequencing technique may overcome these shortcomings, and is gradually being applied in the hospitals. However, it also has a series of disadvantages. This article will review the value of this technique in the detection of sepsis pathogen and the related advantages and disadvantages. |
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| Keywords: | High-throughput sequencing Sepsis Pathogenic microorganisms |
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