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葛根素对大鼠局部脑缺血再灌注损伤皮层钙凋磷酸酶和钙蛋白酶活性的影响
引用本文:高唱,王景周,王琳,周红杰,高东,姚国恩,张莉莉.葛根素对大鼠局部脑缺血再灌注损伤皮层钙凋磷酸酶和钙蛋白酶活性的影响[J].中国急救医学,2002,22(7):379-380.
作者姓名:高唱  王景周  王琳  周红杰  高东  姚国恩  张莉莉
作者单位:第三军医大学大坪医院野战外科研究所神经内科,重庆,400042
摘    要:目的 探讨葛根素在局灶性脑缺血/再灌注过程中抗神经元凋亡的作用及机理。方法 采用大鼠局灶脑缺血模型,观察脑缺血/再灌注后皮层钙凋磷酸酶和钙蛋白酶活性的变化。结果 脑缺血/再灌注可以导致皮层钙凋磷酸酶和钙蛋白酶活性增加,葛根素可降低皮层钙凋磷酸酶和钙蛋白酶活性。结论 葛根素抗缺血神经元凋亡的作用可能与其降低这两种酶的活性有关。

关 键 词:葛根素  脑缺血  神经元凋亡  钙凋磷酸酶  钙蛋白酶  动物模型
文章编号:1002-1949(2002)07-0379-02
修稿时间:2002年2月5日

Effects of Gegensu on cortical calcineurin and calpain activities in focal cerebral ischemic rats
GAO Chang,WANG Jing-zhou,WANG Lin,et al..Effects of Gegensu on cortical calcineurin and calpain activities in focal cerebral ischemic rats[J].Chinese Journal of Critical Care Medicine,2002,22(7):379-380.
Authors:GAO Chang  WANG Jing-zhou  WANG Lin  
Institution:GAO Chang,WANG Jing-zhou,WANG Lin,et al.Department of Neurology,Daping Hospital,the Third Military Medical University,Chongqing 400042,China
Abstract:Objective To explore if the inhibitory effect of Gegensu on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities.Methods After the ischemia/reperfusion model was established in Wistar rat,the changes of the calcineurin and calpain enzymes activities were measured by using biochemical methods.Results Cerebral ischemia/reperfusion could result in the calcineurin and calpain enzymes activities were increased. Gegensu was found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities.Conclusion The anti-apoptotic effect of Gegensu may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.
Keywords:Gegensu  Cerebral ischemia  Apoptosis  Calcineurin  Calpain
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