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| 颅脑外伤急性期低钠血症的临床分析 | |
| 引用本文： | 张文川,郑履平,吴伟烈,徐顺清,刘鸣,张天锡.颅脑外伤急性期低钠血症的临床分析[J].中国急救医学,1999,19(5):272-273. |
| 作者姓名： | 张文川 郑履平 吴伟烈 徐顺清 刘鸣 张天锡 |
| 作者单位： | 1. 上海第二医科大学附属新华医院神经外科,200092 2. 重庆医科大学附属第一医院神经外科 3. 上海第二医科大学附属瑞金医院神经外科 |
| 摘 要： | 目的探讨中枢性低钠血症的病理机制及治疗。方法对６８例急性颅脑外伤（ＡＣＩ）患者血中心钠肽（ＡＮＰ）、脑钠肽（ＢＮＰ）、内源性类洋地黄物质（ＥＤＬＳ）、抗利尿激素（ＡＤＨ）及血尿钠浓度、血尿渗透压作同步测定。结果６８例ＡＣＩ患者中有２７例出现低钠血症，且多集中出现在重伤或特重伤病员中。结论中枢性低钠血症与下丘脑———垂体轴功能受损致ＥＤＬＳ、ＡＤＨ分泌增加相关，血ＡＮＰ、ＢＮＰ浓度降低未直接影响到血钠浓度。静脉给予外源性促甲状腺素释放激素（ＴＲＨ）可以对抗ＡＣＩ患者ＡＤＨ分泌增加所引起的稀释性低钠血症。 |
| 关 键 词： | 急性颅脑外伤 低钠血症 心钠肽 脑钠肽 内源性类洋地黄物质 抗利尿激素 |
The clinical analysis of hyponatremia in acute craniocerebral injury |
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| Zhang Wenchuan,Zheng Lping,Wu Weilie,et al..The clinical analysis of hyponatremia in acute craniocerebral injury[J].Chinese Journal of Critical Care Medicine,1999,19(5):272-273. | |
| Authors: | Zhang Wenchuan Zheng Lping Wu Weilie |
| Institution: | Zhang Wenchuan,Zheng Lping,Wu Weilie,et al. Department of Neurosurgery,XinHua hospital,Shanghai No.2 Medical University,Shanghai 200092 |
| Abstract: | Objective This study aims at exploration of mechanism and therapy of hyonatremia with craniocerebral injury. Methods The changes of atrial natriuretic peptide(ANP), brain natriuretic peptide(BNP), endogenous digitalis-like substance(EDLS), antideuretic hormone(ADH), and serum Na , urine Na , plasma-osmolailty, urine-osmolality were observed in 68 patients with acute craniocerebral injury(ACI). Results6BZThere were 27 hponatremia in 68 patients with ACI and they were found mostly in severe of fetal patients. Conclusion Hyponatremia might be related to abnormal secretion of EDLS and ADH as the result of the hypothalamic-hypophysial system injury, not related to decrease of ANP and BNP. TRH might inhibit water-saline preference by antagonising the increase of ADH. |
| Keywords: | ACIHyponatremiaANPBNPEDLSADHTRH |
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