| 低强度脉冲超声波促进大鼠胫骨骨折愈合中血小板衍生生长因子和胰岛素样生长因子1的表达 |
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| 引用本文： | 李燕如,张长杰,刘汉良.低强度脉冲超声波促进大鼠胫骨骨折愈合中血小板衍生生长因子和胰岛素样生长因子1的表达[J].中国组织工程研究与临床康复,2011,15(46):8635-8638. |
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| 作者姓名： | 李燕如 张长杰 刘汉良 |
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| 作者单位： | 长沙市第三医院,湖南省长沙市,410015 |
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| 摘 要： | 背景:有研究表明低强度脉冲超声波可以促进骨折愈合。目的:观察低强度脉冲超声波对胫骨骨折大鼠血小板衍生生长因子及胰岛素样生长因子1表达的影响。方法:实验采用单侧大鼠胫骨制作闭合骨折大鼠模型,建模后每日进行低强度脉冲超声波治疗。结果与结论:建模后14,21d,低强度脉冲超声波治疗的胫骨骨折模型大鼠骨痂量及厚度明显增高(P<0.05),建模后7,14d,其骨痂血小板衍生生长因子和胰岛素样生长因子1表达也明显增高(P<0.05)。说明低强度脉冲超声波促进大鼠胫骨骨折愈合中血小板衍生生长因子和胰岛素样生长因子1的表达,促进早期软骨细胞成熟和软骨内成骨,从而促进骨折的愈合。
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| 关 键 词： | 低强度脉冲超声波 骨折愈合 胫骨 血小板衍生生长因子 胰岛素样生长因子1 骨组织工程 |
Low-intensity pulsed ultrasound promotes platelet derived growth factor and insulin-like growth factor 1 expression during tibial fracture healing in rats |
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| Li Yan-ru,Zhang Chang-jie,Liu Han-liang.Low-intensity pulsed ultrasound promotes platelet derived growth factor and insulin-like growth factor 1 expression during tibial fracture healing in rats[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(46):8635-8638. |
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| Authors: | Li Yan-ru Zhang Chang-jie Liu Han-liang |
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| Institution: | Li Yan-ru,Zhang Chang-jie,Liu Han-liang Third Hospital of Changsha,Changsha 410015,Hunan Province,China |
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| Abstract: | BACKGROUND:Low-intensity pulsed ultrasound has been demonstrated to promote fracture healing.OBJECTIVE:To investigate the effects of low-intensity pulsed ultrasound on platelet derived growth factor and insulin-like growth factor 1 expression during tibial fracture healing in rats.METHODS:Rat models of closed fracture in unilateral tibia were established and then low-intensity pulsed ultrasound treatment was daily performed.RESULTS AND CONCLUSION:At 14 and 21 days after model preparation,bone calcus amount ... |
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