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| 甲醛熏染模型大鼠肝脏组织增殖细胞核抗原表达与三七复方合剂的干预 | |
| 引用本文： | 王建伟,刘胜勇,雷秀兵,王振宇,成家茂,陈峰,岳兵,王珂,田珑,张卫光.甲醛熏染模型大鼠肝脏组织增殖细胞核抗原表达与三七复方合剂的干预[J].中国组织工程研究与临床康复,2011,15(41):7657-7660. |
| 作者姓名： | 王建伟 刘胜勇 雷秀兵 王振宇 成家茂 陈峰 岳兵 王珂 田珑 张卫光 |
| 作者单位： | 1. 北京大学医学部人体解剖学与组织胚胎学系,北京市,100191 2. 攀枝花学院医学系,四川省攀枝花市,617000 3. 北京大学医学部校医院,北京市,100191 4. 大理学院基础医学院,云南省大理市,671000 |
| 基金项目： | 课题受国家基础科学人才培养基金 |
| 摘 要： | 背景:甲醛作为一种有毒物质可给人体带来严重的损害,同时又缺少有效的防治方法。目的:观察中药三七复方合剂对甲醛熏染大鼠肝细胞增殖的影响。方法:将SD大鼠随机分成对照组、甲醛组和三七治疗组。对照组不做任何处理;甲醛组每天置于静态熏染箱内行甲醛熏染,连续8周;三七治疗组处理同甲醛组,但自第5周起,每日给予三七复方合剂灌胃1次。结果与结论:苏木精-伊红染色结果显示,甲醛熏染8周甲醛组大鼠肝组织肝小叶形态结构紊乱、肝细胞呈现明显的增殖现象,窦间隙缩窄,而三七治疗组肝组织的形态结构明显恢复。免疫组织化学结果显示,甲醛组大鼠肝组织增殖细胞核抗原阳性细胞数明显多于对照组(P<0.01),而三七治疗组与甲醛组相比则明显降低(P<0.01)。结果证实,三七复方合剂能够降低由甲醛诱发的肝组织增殖细胞核抗原的表达,可有效减缓由甲醛诱发的大鼠肝细胞增殖。 |
| 关 键 词： | 三七 甲醛 肝脏 增殖细胞核抗原 组织构建 |
Effects of compound panax notoginseng on proliferating cell nuclear antigen expression in liver tissue of rats exposed to formaldehyde vapor |
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| Wang Jian-wei,Liu Sheng-yong,Lei Xiu-bing,Wang Zhen-yu,Cheng Jia-mao,Chen Feng,Yue Bing,Wang Ke,Tian Long,Zhang Wei-guang.Effects of compound panax notoginseng on proliferating cell nuclear antigen expression in liver tissue of rats exposed to formaldehyde vapor[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(41):7657-7660. | |
| Authors: | Wang Jian-wei Liu Sheng-yong Lei Xiu-bing Wang Zhen-yu Cheng Jia-mao Chen Feng Yue Bing Wang Ke Tian Long Zhang Wei-guang |
| Institution: | Wang Jian-wei1,Liu Sheng-yong1,Lei Xiu-bing2,Wang Zhen-yu3,Cheng Jia-mao4,Chen Feng1,Yue Bing1,Wang Ke1,Tian Long1,Zhang Wei-guang1 1Department of Anatomy,Histology and Embryology,Peking University Health Science Center,Beijing 100191,China,2Department of Medicine,Panzhihua University,Panzhihua 617000,Sichuan Province,3Hospital of Peking University Health Science Center,4School of Basic Medical Sciences,Dali University,Dali 671000,Yunnan Province |
| Abstract: | BACKGROUND:Formaldehyde is a commonly used chemical substance which can cause serious damage to the body as a toxicant,and there is lack of effective control methods.OBJECTIVE:To explore the curative effect of compound panax notoginseng(CPN) on the proliferation of hepatic cells of Sprague-Dawley rats exposed to formaldehyde vapor.METHODS:Eighteen Sprague-Dawley male rats were randomly divided into three groups:control,formaldehyde and CPN.Nothing was done to the control group rats.The formaldehyde group ra... |
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