青少年脊柱侧凸畸形与褪黑素:海口市10余所城乡中小学8198名青少年普查结果分析

背景对于褪黑素是否与特发性脊柱侧凸(AIS)的发病机制有关,目前国内外学者研究结果尚无统一认识.目的探讨青少年脊柱侧凸发病机制与褪黑素的关系及作用.设计两检筛选法普查及非随机化同期对照研究.单位海口市人民医院骨二科.对象实验在海口市人民医院骨二科完成.调查海府地区10余所城乡中小学8 198名7～16岁在校学生,其中男4 423名,女3 775名.方法选择普查中被诊断为AIS患儿42名,随机抽取50名正常人做对照,用放免法进行褪黑素测定与统计学处理.主要观察指标两组调查者血清褪黑素含量.结果青春前期10岁前年龄段AIS男女初始组褪黑素含量均低于青春期组及正常组,尤以女性为显,具有高度统计学意义.结论血清中褪黑素与脊柱侧凸的发病机制有关.

Adolescent idiopathic scoliosis and melatonin: a survey on scoliosis in 8 198 adolescents from over 10 middle and primary schools in Haikou City

BACKGROUD: It is not consistent on whether melatonin correlates with the adolescent idiopathic scoliosis(AIS) demonstrated by the domestic and foreign scholars.OBJECTIVE: To study the pathogenesis of AIS and its correlation with melatonin.DESIGN: A nonrandomized age-matched controlled study screened with two tests.SETTING: The Second Department of Orthopaedics, Haikou People' s Hospital.PARTICIPANTS: The experiment was completed in the Second Department of Orthopaedics, Haikou People' s Hospital. Totally 8 198 in-school students.from over 10 schools of towns in Haifu District, 4 423 males and 3 775 females, aged 7 to 16 years were surveyed.METHODS: Forty-two adolescents who have been diagnosed with AIS were selected and 50 healthy age-matched adolescents were selected as controls. Melatonin was assayed with the radioimmunology and the data were processed statistically.MAIN OUTCOME MEASURES: The levels of serum melatonin in the two groups.RESULTS: The serum melatonin of the preadolescents below 10 years old in AIS group, especially of females, was less than that of adolescents in the control group, with significant differencein statistics.CONCLUSION: The serum melatonin correlates with pathogenesis of AIS.