不同压力弹力绷带对抑制瘢痕增生的影响

目的:观察不同压力对增生瘢痕微循环的影响.方法:选择肢体烧伤愈合后瘢痕增生患者60例,男49例,女11例,平均年龄37岁,依弹力绷带加压压力不同,以抽签法随机分为3组:低压力组(压力0.67～1 33 kPa),常规压力组(压力1.33～3.33 kPa),高压力组(压力3.33～6.67 kPa).所选病例均在创面愈合后1周时开始弹力绷带加压,加压压力循序渐进逐渐增加,至5～7 d后达到预期压力值,持续6个月后使用激光多普勒血流图像诊断技术测定不同压力下瘢痕组织表面血流灌注量的变化.结果:按意向性处理分析,60例患者全部进入结果分析.3组加压前瘢痕组织表面血流灌注量比较差异无显著性意义.加压后,低压力组瘢痕组织表面血流灌注量值较加压前下降,但差异无显著性意义(P＞0.05);常规压力与高压力组瘢痕组织表面血流灌注量值均较加压前下降(P＜0.05),高压力组瘢痕组织表面血流灌注量值低于常规加压组(P＜0.05).当加压压力增加到3.33～6.67 kPa时,患者加压肢体憋胀不适感加重,个别病例加压肢体远端出现肿胀迹象,其中2例因无法坚持而退出实验.结论:采用弹力绷带加压3.33 kPa可明显降低瘢痕组织表面血流灌注量,抑制瘢痕增生,加压压力应逐渐增大,在患者能够耐受的前提下,压力越大效果越明显.

Influence of different pressure tension bandage on inhibiting scar proliferation

OBJECTIVE: To explore the effect of different pressure on microcirculation of scar proliferation. METHODS: A total of 60 patients with scar proliferation after burning were collected, including 49 males and 11 females, with averagely aged 37 years. The patients were divided into low pressure (0.67-1.33 kPa), normal pressure (1.33-3.33 kPa) and high pressure (3.33-6.67 kPa) groups by envelope method. Pressure tension bandage was used at 1 week after wound healing and gradually increased, reached expected pressure at days 5-7 and sustained for 6 months. Then the changes of blood perfusion at the scar tissue were measured by laser Doppler perfusion imaging (LDPI). RESULTS: According to the intended processing analysis, all the 60 patients enter the result analysis. There were no significant differences of the scar tissue perfusion of the 3 groups before the therapy. After the therapy, the perfusion was decreased in the low pressure group, but there are no statistical changes compared to before the therapy (P > 0.05), while the perfusion was decreased in the normal pressure and high pressure groups (P < 0.05), which was lower in the high pressure group than the normal pressure group (P < 0.05). When the pressure increased to 3.33-6.67 kPa, the patients feel much more uncomfortable and the swelled signs appear, and 2 patients quit the experiment. CONCLUSIONS: The scar tissue perfusion is decreased obviously when adding the pressure to 3.33 kPa by using tension bandage. Using this method, the pressure should gradually increase to the maximum if patients can bear.