| 骨保护蛋白和骨保护蛋白配体在脊柱结核病灶骨中的表达 |
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| 引用本文： | 何玉泽,王自立,马腾,辛兵,郭开今. 骨保护蛋白和骨保护蛋白配体在脊柱结核病灶骨中的表达[J]. 中国组织工程研究与临床康复, 2011, 15(28): 5165-5168. DOI: 10.3969/j.issn.1673-8225.2011.28.009 |
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| 作者姓名： | 何玉泽 王自立 马腾 辛兵 郭开今 |
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| 作者单位： | 1. 徐州医学院附属医院骨科,江苏省徐州市,221002
2. 宁夏医科大学附属医院骨科,宁夏回族自治区银川市,750004 |
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| 摘 要： | 背景:脊柱结核病灶骨组织硬化的病理过程较为复杂,其发生机制尚不明确。目的:探讨脊柱结核病灶骨不同部位的骨保护蛋白和骨保护蛋白配体的表达。方法:取脊柱结核患者脊柱结核术中切除的骨质,按照部位分成硬化骨组,亚正常骨组和正常骨组。应用PV-6000二步法免疫组化检测技术测定各组标本中骨保护蛋白和骨保护蛋白配体的平均吸光度及阳性面积比,并进行统计学分析。结果与结论:脊柱结核硬化骨组骨保护蛋白平均吸光度,阳性面积比以及骨保护蛋白和骨保护蛋白配体表达的比值均显著高于亚正常骨组和正常骨组(P<0.01或P<0.05)。结果表明骨保护蛋白和骨保护蛋白配体的表达变化与脊柱结核病灶周围硬化骨的产生有关。
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| 关 键 词： | 脊柱结核 硬化骨 骨保护蛋白 骨保护蛋白配体 免疫组化 |
Expression of osteoprotegerin and osteoprotegerin ligand in the focus of spinal tuberculosis |
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| He Yu-ze,Wang Zi-li,Ma Teng,Xin Bing,Guo Kai-jin. Expression of osteoprotegerin and osteoprotegerin ligand in the focus of spinal tuberculosis[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(28): 5165-5168. DOI: 10.3969/j.issn.1673-8225.2011.28.009 |
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| Authors: | He Yu-ze Wang Zi-li Ma Teng Xin Bing Guo Kai-jin |
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| Affiliation: | He Yu-ze1,Wang Zi-li2,Ma Teng2,Xin Bing1,Guo Kai-jin1 1Department of Orthopedics,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,Jiangsu Province,China,2Department of Orthopedics,Affiliated Hospital of Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region |
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| Abstract: | BACKGROUND:The pathological process of bone tissue hardening in spinal tuberculosis is complex, and the underlying mechanism remains poorly understood. OBJECTIVE:To investigate the expression of osteoprotegerin (OPG) and OPG ligand (OPGL) in different sections of spinal tubercular infectious focus. METHODS: The bones resected from patients with spinal tubereculosis were divided into three groups based on their regions:ossified bone, sub-normal bone and normal bone. The average absorbance and positive area p... |
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