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| 肌肉生长抑制素基因多态性与肌肉生长敏感性的关联 | |
| 引用本文： | 李晓,刘丽红,马力宏.肌肉生长抑制素基因多态性与肌肉生长敏感性的关联[J].中国组织工程研究与临床康复,2011,15(28). |
| 作者姓名： | 李晓 刘丽红 马力宏 |
| 作者单位： | 1. 焦作师范高等专科学校体育系,河南省焦作市,454152 2. 大连医科大学基础医学院,辽宁省大连市,116044 3. 天津体育学院运动人体科学系,天津市,300381 |
| 摘 要： | 背景:肌肉生长抑制素(growth differentiation factor 8,GDF-8)基因在人类中对于调节肌肉生长起重要的作用.但关于中国人群该基因的研究甚少.目的:实验从肌肉生长抑制素基因多性AluⅠ酶切位点限制性酶切位点入手,观察GDF-8基因多性与人体肌肉生长的关联.方法:选取天津体育学院无训练汉族学生92名,进行为期2个月的力量训练,用B超测定运动前后肱二头肌和股四头肌的肌肉厚度.测试训练前后形态学各指标包括身高、体质量、体脂肪含量、瘦体质量的变化、运动前后肱二头肌和股四头肌的肌肉厚度变化趋势以及在GDF-8 AluⅠ酶切位点限制性酶切位点上的差异.含AluⅠ位点片段由引物扩增后长度为135 bp,定义为A,经AluⅠ限制性酶切割后,含有AluⅠ酶切位点的等位基因出现80,55 bp的片段,定义为T,这样即出现3种基因型AA,AT和TT.结果与结论:从形态学指标上受试者群体在AluⅠ位点上A/T杂合子及T/T纯合子在身高,训练前后的体质量,瘦体质量,肌肉厚度和肱二头肌及股四头肌直径厚度上均高于A/A纯合子(P < 0.05或P < 0.01).结果证实,AluⅠ位点多态性与人体身高,体质量及瘦体质量关联,等位基因T为肌肉生长的先天敏感因子. |
| 关 键 词： | 肌肉肥大 肌肉生长抑制素 力量训练 基因多态性 关联研究 |
Association of myostatin polymorphism with sensitivity to muscular growth |
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| Li Xiao,Liu Li-hong,Ma Li-hong.Association of myostatin polymorphism with sensitivity to muscular growth[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(28). | |
| Authors: | Li Xiao Liu Li-hong Ma Li-hong |
| Institution: | Li Xiao1,Liu Li-hong2,Ma Li-hong3 1Department of Physical Education,Jiaozuo Teachers College,Jiaozuo 454152,Henan Province,China,2Basic Medical College of Dalian Medical University,Dalian 116044,Liaoning Province,3Department of Sport Physiology,Tianjin University of Sport,Tianjin 300381 |
| Abstract: | BACKGROUND:The myostatin plays an important role in the regulation of muscular growth in human body, however, there is few study regarding this gene in Chinese populations. OBJECTIVE:To elucidate the association of growth differentiation factor 8 (GDF-8) gene polymorphism and human muscles through the observation of the Alu I restriction site of GDF-8 gene polymorphism. METHODS:A total of 92 undisciplined male students, of Han population, received strength training for 8 weeks at Tianjin University of Sport... |
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