| 尼莫通对急性脑缺血保护作用临床及实验研究 |
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| 引用本文： | 李秀珍,孙运娟,王风焰,陈沛源,王立文,万太玉.尼莫通对急性脑缺血保护作用临床及实验研究[J].中国组织工程研究与临床康复,2000,4(1):76-77. |
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| 作者姓名： | 李秀珍 孙运娟 王风焰 陈沛源 王立文 万太玉 |
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| 作者单位： | 1. 解放军第456医院,山东,济南,250031
2. 山东省人民医院 |
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| 摘 要： | 目的 :探讨尼莫通对急性脑缺血再灌流保护作用机制。方法 ;采用家兔四动脉闭塞脑缺血灌流动物模型 ,检测脑缺血再灌流前后血清丙二醛(MDA)、超氧化物歧化酶(SOD)变化及脑组织H2O、Na 、K 、Ca 含量 ;同时进行了55例脑梗塞患者分组对照。结果 :再灌流后尼莫通组与其它组相比MDA下降、SOD升高均显著。结论 :尼莫通通过阻止Ca 内流抑制脂质过氧化损伤 ,对脑缺血具有保护作用
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| 关 键 词： | 脑梗塞 脑缺血 自由基 尼莫通 钙 |
Protective
effect of Nimotop on cerebral ischemia in clibnic and experimental study |
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| LI Xiu_zhen,SUN Yun_juan,et al..Protective
effect of Nimotop on cerebral ischemia in clibnic and experimental study[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2000,4(1):76-77. |
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| Authors: | LI Xiu_zhen SUN Yun_juan |
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| Institution: | LI Xiu_zhen,SUN Yun_juan,et al.No.456 Hospital of the PLA,Jinan 250031,China. |
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| Abstract: | Objective:To study protective mechanism of Nimotop from injury of cerebral ischmia_reperfusion.Method:A model of cerebral ischemia_repefusion injury was performed by clipping four arteries and then by releasing them to reperfuse blood by into the ischmic brain in rats.The changes of MDA and SOD in serum and H2O,Na ,K ,Ca ,in brain tissue were measured before and after cerebral ischmia repefusion.At the same time 55 patients with cerbral infarction were studied.Results:After treatment with Nimotop content of MDA was signifcantly decreased,activity of SOD was significantly increasec in rats and patients. Conclusion:Nimotop protects brain tissue from cerebral ischmia by inhibiting calcium influx and lipo_hyperoxidation. |
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| Keywords: | cerebral ischmia cerebral infarction free radical Nimotop calcium |
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