药物靶向、分子靶向、激素靶向及干细胞靶向与骨质疏松症的治疗

背景:骨质疏松症引起的骨折及其他并发症严重影响中老年人生活质量。目的:探讨靶向疗法治疗骨质疏松的进展,以促进其临床应用。方法:由第一作者应用计算机检索PubMed、中国期刊全文数据库(CNKI)中1997-05/2011-12相关文献。在标题、摘要、关键词中以"targeted therapy,bone target,stem cell,osteoporosis,treatment"或"靶向治疗,骨靶向,干细胞,骨质疏松,治疗"为检索词进行检索。选择文章内容与靶向疗法治疗骨质疏松有关者,同一领域则选择近期发表在权威杂志上的文章。结果与结论:初检得到148篇文献,根据纳入标准选择38篇文献进行综述。靶向治疗骨质疏松已成为骨质疏松治疗中的研究热点。目前研究领域涉及药物靶向、分子靶向、激素靶向、受体靶向及干细胞靶向治疗等,其中药物、分子及激素靶向疗法为目前常用的治疗方法,常用药物有四环素、双膦酸盐类、Denosumab等。但目前靶向治疗骨质疏松尚未完全成熟,所导致的临床不良反应限制其应用进展,仍有许多问题有待解决。

Drug-,molecular-,hormone-and stem cells-targeted therapies for osteoporosis

BACKGROUND:Osteoporosis fractures and other complications can result in a severe impact in the quality of life of older people.OBJECTIVE:To explore the progress in targeted therapy for osteoporosis in order to promote its clinical application.METHODS:A computer-based online search of PubMed database and CNKI database between May 1997 and December 2011 was performed to search related articles with the Key words of "targeted therapy,bone target,stem cell,osteoporosis,treatment" in English and Chinese,respectively.Literatures related to targeted therapy for osteoporosis on osteoporosis were selected;in the same field,the articles published lately in authoritative journals were preferred.RESULTS AND CONCLUSION:A total of 148 literatures were primarily selected,and 38 documents were involved for summary according to inclusion criteria.Targeted treatment of osteoporosis has become a focus in the treatment of osteoporosis.Current research involves drug-targeted,molecular-targeted,hormone-targeted,receptor-targeted and stem cell-target therapies.Drug-,molecular-and hormone-targeted therapies are the most common methods to treat osteoporosis.Commonly used drugs include tetracycline,bisphosphonates,denosumab.However,targeted therapy for osteoporosis has not yet fully mature,and its clinical side effects limit its further development that there are still many issues to be resolved.