| 潍坊地区汉族人群PON1(对氧磷酶)Q192R基因多态性与冠心病的相关性研究 |
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| 引用本文： | 邢旭东,刘焕荣,翟振道,秦浩,季祥武.潍坊地区汉族人群PON1(对氧磷酶)Q192R基因多态性与冠心病的相关性研究[J].中国误诊学杂志,2009,9(5). |
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| 作者姓名： | 邢旭东 刘焕荣 翟振道 秦浩 季祥武 |
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| 作者单位： | 1. 山东省昌邑市人民医院,261300
2. 潍坊医学院 |
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| 摘 要： | 目的:测定PON1(对氧磷酶)Q192R基因多态性及在人群中的分布,分析各基因型与冠心病的关系。方法:冠心病患者128例,男80例,女48例,年龄为36~82(65.25±9.83)岁,全部病例有明确心梗病史或经冠状动脉(冠脉)造影确诊。正常对照组110例,男66例,女44例,年龄31~87(63.52±7.91)岁,选自人群健康查体的随机个体。结果:PON1Q192R有QQ、QR、RR三种基因型,正常人的基因型频率分别为0.200 0、0.490 9、0.309 1,冠心病组QQ、QR、RR三种基因频率分别为0.226 6、0.531 3、0.242 1。结论:潍坊地区汉族人群PON1(对氧磷酶)基因多态性和冠心病无关。
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| 关 键 词： | 芳基二烷基磷酸酶/遗传性 多态现象 遗传 冠状动脉疾病/酶学 人类 山东 |
Study on PON1 Gene Polymorphism and Association of PON1 polymorphism With Coronary Heart Disease among Chinese Han Population of Weifang District |
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| Institution: | XING Xu-dong; LIU Huan-rong; ZHAI Zhen-dao; et al.(The People Hospital of Changyi; Changyi 261300; Shandong; China); |
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| Abstract: | Objective:To investigate the distribution of the Q/R polymorphism of PON1 gene in Chinese Han nationality and to analyze the association of PON1 gene with coronary atherosclerotic heart disease(CHD).Methods:128 patients with CHD (80men and 48 women,mean age 65.25±9.83 years) and 110 unrelated health individuals(66men and 44 women,mean age 63.52±7.919 years) were studied.ALL patients had the history of MI or were confirmed by coronary angiography.There was no relationship between individuals in the study pop... |
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| Keywords: | Aryldialkylphosphatase/genetics Polymorphism Genetic Coronary Disease/enzymology Humans SHANDONG |
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