血清心肌肌钙蛋白T、CRP水平与维持性血液透析患者预后的相关性研究

目的探讨影响维持性血液透析(MHD)患者预后的相关因素。方法 105例MHD患者,随访2年,统计患者临床资料,记录随访结果,分析C-反应蛋白(CRP)和血清心肌肌钙蛋白T(c Tn T)与MHD患者预后的关系。结果 105例MHD患者平均随访(20.68±1.32)个月,其中血清c Tn T阳性27例(25.71%),血清CRP阳性31例(29.52%),两者均阳性15例(14.29%),随访期间死亡21例(20.00%)。c Tn T阳性患者的死亡率显著高于其阴性患者(P0.01),CRP阳性患者的死亡率显著高于其阴性患者(P0.01),两者均为阳性患者的死亡率显著高于均为阴性和阴阳合并的患者(P0.05或P0.01)。生存分析显示,c Tn T阳性、CRP阳性及两者均为阳性对MHD患者的生存有显著影响。结论血清c Tn T和CRP水平与MHD患者预后具有显著的相关性。

Study on the correlation between the levels of serum cardiac troponin T,C-reactive protein and the prognosis in patients with maintenance hemodialysis

Objective To explore the relevant influencing factors of the prognosis of patients with maintenance hemodialysis (MHD).Methods Totally 105 patients with MHD were followed up for two years.Their clinical data were collected,and follow-up results were recorded.The relationships between C-reactive protein (CRP),serum cardiac troponin T (cTnT) and the prognosis of patients with MHD were analyzed.Results A total of 105 patients with MHD were followed up for (20.68 ± 1.32) months,in which there were 27 cases (25.71％) with positive cTnT,31 cases (29.52％) with positive CRP,and 15 cases (14.29％) with positive cTnT and CRP.Twenty-one cases (20.00％) were dead in follow-up period.The mortality of patients with sample positive cTnT or CRP was significantly higher than those with sample negative cTnT or CRP (P ＜ 0.01),and the mortality of patients with both positive cTnT and CRP was markedly higher than those with both negative ones and those with one positive and one negative (P ＜ 0.05 or P ＜0.01).Survival analysis revealed that the survival of patients with MHD was significantly correlated with the influence of positive cTnT,positive CRP and positive cTnT and CRP.Conclusion The levels of serum cTnT and CRP are significantly correlated with the prognosis of patients with MHD.