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乳腺癌改良根治术后大分割放疗的临床研究
引用本文:毕利萍,李玉军,宫学华,刘莹,张洪岩.乳腺癌改良根治术后大分割放疗的临床研究[J].实用临床医药杂志,2011,15(13).
作者姓名:毕利萍  李玉军  宫学华  刘莹  张洪岩
作者单位:中国石油天然气集团公司中心医院,放疗科,河北,廊坊,065000
摘    要:目的研究局部晚期乳腺癌改良根治术后大分割放疗与常规分割放疗的疗效、副反应。方法 100例局部晚期乳腺癌病例,病人均接受乳腺癌改良根治术和术后6~8周期化疗,随机分为大分割放疗和常规分割放疗2组:大分割放射治疗组2.9 Gy/次,每周5次,总剂量43.5 Gy;常规分割治疗组2 Gy/次,每周5次,总剂量50 Gy。结果大分割放射治疗组和常规分割放射治疗组的3年总生存率分别为82.4%和85.7%,局部区域复发率分别为7.8%和6.1%,急性2~3级放射性皮肤损伤发生率分别为7.8%和6.1%(P>0.05),两组均无严重的后期反应发生(臂丛损伤、皮肤溃疡形成、放射性肺炎等),心电图所示两组心肌缺血性改变也无明显差别。结论大分割放射治疗缩短了治疗时间,其总生存率及局部复发率、疗后毒副作用与常规分割放射治疗无明显差异,可作为局部晚期乳腺癌改良根治术后常规辅助放疗的替代放疗方案。

关 键 词:乳腺癌  改良根治术  大分割放疗  预后  副反应

Clinical study of hypofractionated radiotherapy in breast cancer after modified radical mastectomy
BI Li-ping,LI Yu-jun,GONG Xue-hua,LIU Ying,ZHANG Hong-yan.Clinical study of hypofractionated radiotherapy in breast cancer after modified radical mastectomy[J].Journal of Clinical Medicine in Practice,2011,15(13).
Authors:BI Li-ping  LI Yu-jun  GONG Xue-hua  LIU Ying  ZHANG Hong-yan
Institution:BI Li-ping,LI Yu-jun,GONG Xue-hua,LIU Ying,ZHANG Hong-yan(The Central Hospital of China National Petroleum Corporation,Langfang,Heibei,065000)
Abstract:Objective To study the effect and toxicity of post-mastectomy radiotherapy with different fractionated dose schemes for local advanced breast cancer.Methods A total of 100 patients with local advanced breast cancer,who received mastectomy and 6~8 cycles of chemotherapy after the surgery,were randomized to hypofractionation group and conventional fractionation group.The hypofractionation group received 43.5Gy(2.9 Gy per fraction and five fraction per week);the conventional group received 50 Gy(2.0 Gy per fra...
Keywords:breast carcinoma  modified mastectomy  hypofractionation  prognosis  toxicity  
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