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含铂双药方案治疗老年非小细胞肺癌的疗效和安全性分析
引用本文:高作文,娄金书,丁太良,徐圆,宋德生.含铂双药方案治疗老年非小细胞肺癌的疗效和安全性分析[J].实用临床医药杂志,2012,16(22):59-61.
作者姓名:高作文  娄金书  丁太良  徐圆  宋德生
作者单位:解放军86医院肿瘤科,安徽当涂,243100
摘    要:目的观察顺铂联合长春瑞滨、多西他赛或吉西他滨治疗老年非小细胞肺癌的疗效和安全性。方法回顾性研究分别接受长春瑞滨+顺铂、多西他赛+顺铂和吉西他滨+顺铂方案化疗的114例老年非小细胞肺癌的疗效和副反应。结果 3组治疗的有效率分别为35.71%、39.39%、35.9%。副反应以骨髓抑制常见,白细胞减少3级以上者3组分别为26.2%、33.3%、23.1%,3级以上的血小板减少及贫血在全组病例发生率分别为5.26%、0.88%。结论年龄不是含铂双药化疗的禁忌,老年晚期非小细胞肺癌患者可接受含铂的双药方案化疗,并能取得一定近期疗效。

关 键 词:顺铂  长春瑞滨  多西他赛  吉西他滨  非小细胞肺癌  老年

Efficacy and safety analysis of platinum doublet chemotherapy on non-small cell lung cancer in the elderly patients
GAO Zuowen , LOU Jinshu , DING Tailiang , XU Yuan , SONG Desheng.Efficacy and safety analysis of platinum doublet chemotherapy on non-small cell lung cancer in the elderly patients[J].Journal of Clinical Medicine in Practice,2012,16(22):59-61.
Authors:GAO Zuowen  LOU Jinshu  DING Tailiang  XU Yuan  SONG Desheng
Institution:(The 86th Hospital of the People′s Liberation Army,Dangtu,Anhui,243100)
Abstract:Objective To observe the efficacy and safety of cisplatin plus vinorelbine,docetaxel or gemcitabine in the treatment of elderly patients with advanced non-small cell lung cancer(NSCLC).Methods A total of 114 elderly patients with NSCLC were treated with vinorelbine plus cisplatin(NP),docetaxel plus cisplatin(DP) and gemcitabine plus cisplatin(GP) chemotherapy respectively.The efficacy and side effects were observed.Results The overall response rate was 35.71% for NP group,39.39% for DP group,and 35.9% for GP group.Common side effects were bone marrow suppression,leukopenia occured in grade Ⅲ/Ⅳ were 26.2% in NP group,33.3% in DP group,23.1% in GP group,thrombocytopenia and anemia occurred in grade Ⅲ/Ⅳ were 5.26% and 0.88% in the whole group.Conclusion The dual-drug containing platinum regimens were effective and safe for elderly patients with advanced non-small cell lung cancer patients.
Keywords:cisplatin  vinorelbine  docetaxel  gemcitabine  non-small cell lung cancer  elderly
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