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| 白芍总苷对接触性皮炎小鼠核因子-κB、CD1a因子、肿瘤坏死因子的影响 | |
| 引用本文： | 陈菲菲,朱晓芳,高慧,骆丹.白芍总苷对接触性皮炎小鼠核因子-κB、CD1a因子、肿瘤坏死因子的影响[J].实用临床医药杂志,2010,14(11). |
| 作者姓名： | 陈菲菲 朱晓芳 高慧 骆丹 |
| 作者单位： | 1. 南京医科大学第一临床医学院,江苏,南京,210009;扬州大学临床医学院,皮肤科,江苏,扬州,225001 2. 扬州大学临床医学院,皮肤科,江苏,扬州,225001 3. 南京医科大学第一临床医学院,江苏,南京,210009 |
| 基金项目： | 江苏省扬州市科技攻关资助项目 |
| 摘 要： | 目的探讨白芍总苷对小鼠变应性接触性皮炎(ACD)的治疗作用。方法以2,4-二硝基氟苯(DNFB)对小鼠进行皮肤致敏及激发,制成小鼠接触性皮炎模型,观察白芍总苷对小鼠耳肿胀度、组织病理改变及皮损处核因子-κB(NF-κB)、CD1a因子表达及血清肿瘤坏死因子(TNF-α)水平的影响。结果白芍总苷能显著抑制ACD小鼠的耳肿胀度,可降低诱发后的小鼠血清TNF-α水平,下调NF-κB、CD1a的表达。结论白芍总苷对小鼠ACD有治疗作用,这与其下调炎性细胞因子水平有关,也可能与下调NF-κB、CD1a的表达有关。 |
| 关 键 词： | 白芍总苷 接触性皮炎 肿瘤坏死因子(TNF-α) 核因子-κB(NF-κB) CD1a |
Effects of total glucosides of paeony on murine allergic contact dermatitis |
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| CHEN Fei-fei,ZHU Xio-fang,GAO Hui,LUO Dan.Effects of total glucosides of paeony on murine allergic contact dermatitis[J].Journal of Clinical Medicine in Practice,2010,14(11). | |
| Authors: | CHEN Fei-fei ZHU Xio-fang GAO Hui LUO Dan |
| Abstract: | Objective To study the effects and mechanisms of Total Glucosides of Paeony on murine allergic contact dermatitis(ACD).Methods The murine model of ACD induced by 2,4-dinitrofluorobenzene(DNFB)was established.Observe the effect of Total Glucosides of Paeony(TGP)on murine ear swelling,histopathological changes,the levels of NF-κB、CD1a by immunohistochemical method and the levels of serum TNF-α.Results Murine ear swellings were suppressed by TGP,and TGP could down-regulate the level of serum TNF-αand the expressions of NF-κB、CD1a in skin lesions.Conclusion TGP has therapeutic effects on murine ACD,which is probably related to the down-regulation of the expressions of cytokines and alsothe expressions of NF-κB and CD1a. |
| Keywords: | CD1a |
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