| 恩度联合化疗治疗非小细胞肺癌的疗效研究 |
| |
| 引用本文： | 汪宏斌,杨俊泉,刘宏侠,徐艺东,王晓红,孙玉满,谷守琦,李红民.恩度联合化疗治疗非小细胞肺癌的疗效研究[J].实用临床医药杂志,2011,15(17):98-101. |
| |
| 作者姓名： | 汪宏斌 杨俊泉 刘宏侠 徐艺东 王晓红 孙玉满 谷守琦 李红民 |
| |
| 作者单位： | 1. 河北省唐山市人民医院放化科,河北唐山,063001
2. 河北省唐山市协和医院病理科,河北唐山,063004 |
| |
| 摘 要： | 目的研究重组人血管内皮抑制素(恩度)联合GP或TP方案化疗治疗晚期非小细胞肺癌(NSCLC)的疗效。方法选择62例晚期NSCLC患者,分为2组,实验组30例,予GP或TP方案化疗+恩度治疗,恩度7.5 mg/m2第1~14天连续给药,间隔7 d后重复;对照组32例,予单纯GP或TP方案治疗。所有患者至少完成2周期治疗,评判疗效及生活质量(QOL),治疗1周期后评价药物毒副反应。结果实验组有效率(43.3%)与对照组(37.5%)比较,无统计学差异;实验组疾病控制率(86.7%)明显高于对照组(62.5%);试验组中位总生存期(OS)(15个月)、中位无进展生存期(PFS)(10个月)明显长于对照组(10个月、5个月);咳嗽、疲劳积分显示实验组有缓解优势;实验组功能积分改善有优于对照组趋势,但无统计学差异;2组患者不良反应无明显差异。结论恩度联合GP或TP方案化疗治疗晚期NSCLC可提高疾病控制率、中位OS及PFS,且安全性好。
|
| 关 键 词： | 非小细胞肺癌 重组人血管内皮抑制素 吉西他滨/顺铂 紫杉醇/顺铂 EORTCQLQ-C30 EORTCQLQ-LC13 |
Research on efficacy of rh-endostatin combined with chemotherapy for non-small cell lung cancer |
| |
| WANG Hong-bin,YANG Jun-quan,LIU Hong-xia,XU Yi-dong,WANG Xiao-hong,SUN Yu-man,GU Shou-qi,LI Hong-min.Research on efficacy of rh-endostatin combined with chemotherapy for non-small cell lung cancer[J].Journal of Clinical Medicine in Practice,2011,15(17):98-101. |
| |
| Authors: | WANG Hong-bin YANG Jun-quan LIU Hong-xia XU Yi-dong WANG Xiao-hong SUN Yu-man GU Shou-qi LI Hong-min |
| |
| Institution: | 1.Tangshan People′s Hospital,Tangshan,Hebei,063001;2.Tangshan Xiehe Hospital,Tangshan,Hebei,063004) |
| |
| Abstract: | Objective To investigate the efficacy and safety of the treatment of recombinant human endostatin(Endostar) combined with gemcitabine/cisplatin regiment(GP) or paclitaxel/cisplatin regiment(TP) chemotherapy for advanced non-small cell lung cancer(NSCLC).Methods Sixty-two cases of advanced NSCLC were divided into two groups.The trial group(n=30) received TP or GP regimen chemotherapy plus Endostar(7.5 mg/m2,dl to d14,repeated every 21 days) for at least 2 cycles.The control group(n=32) received TP or GP regi... |
| |
| Keywords: | carcinoma non-small cell lung recombinant human endostatin GP regimen TP regimen EORTC QLQ-C30 EORTC QLQ-LC13 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
